Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges

Shane M. Colley, Peter J. Leedman

Research output: Contribution to journalReview article

66 Citations (Scopus)

Abstract

Steroid Receptor RNA Activator (SRA) occupies a unique and enigmatic position within the nuclear receptor (NR) field and more broadly in transcriptional regulation. This is as a result of its transcripts having both coding and non-coding coactivator activities along with its protein product SRAP performing mixed coactivator/repressor functions. Recent publications have provided greater understanding of SRA gene product activities and how they affect not only NR function, but now more broadly, signalling pathways involved in differentiation and metabolism. This review will discuss the isolation of SRA, its gene products, regulation of transcription along with its in vitro and in vivo activities with a particular focus on its actions as an RNA and its binding partners.

Original languageEnglish
Pages (from-to)1966-1972
Number of pages7
JournalBiochimie
Volume93
Issue number11
DOIs
Publication statusPublished - Nov 2011

Fingerprint Dive into the research topics of 'Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges'. Together they form a unique fingerprint.

Cite this