Stem cells: A recapitulation of development

Yuben Moodley, Philip Thompson, D. Warburton

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Pluripotent stem cells are cells that can differentiate into any tissue from all germ layers and include embryonic stem cells and induced pluripotent cells (iPS). Embryonic stem cells are derived from 8-day blastocysts obtained from unutilized embryos following in vitro fertilization, while iPS is obtained following transfection of dermal fibroblasts with pluripotent genes (sex determining region Y-binding, Kruppel-like factor 4, octamer-binding transcription factor 4 and c-Myc). The major challenge is to differentiate these cells into lung epithelium for therapeutic applications as well as to model lung diseases such as cystic fibrosis. In this review, the developmental pathways of the lung and how these pathways have been recapitulated in vitro to induce differentiation of pluripotent cells to lung epithelium were examined. © 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.
Original languageEnglish
Pages (from-to)1167-1176
JournalRespirology
Volume18
Issue number8
DOIs
Publication statusPublished - 2013

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Stem Cells
Embryonic Stem Cells
Lung
Octamer Transcription Factors
sry Genes
Epithelium
Germ Layers
Pluripotent Stem Cells
Blastocyst
Fertilization in Vitro
Cystic Fibrosis
Lung Diseases
Transfection
Cell Differentiation
Embryonic Structures
Fibroblasts
Skin
Therapeutics

Cite this

Moodley, Yuben ; Thompson, Philip ; Warburton, D. / Stem cells: A recapitulation of development. In: Respirology. 2013 ; Vol. 18, No. 8. pp. 1167-1176.
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Moodley, Y, Thompson, P & Warburton, D 2013, 'Stem cells: A recapitulation of development' Respirology, vol. 18, no. 8, pp. 1167-1176. https://doi.org/10.1111/resp.12186

Stem cells: A recapitulation of development. / Moodley, Yuben; Thompson, Philip; Warburton, D.

In: Respirology, Vol. 18, No. 8, 2013, p. 1167-1176.

Research output: Contribution to journalReview article

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AU - Moodley, Yuben

AU - Thompson, Philip

AU - Warburton, D.

PY - 2013

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