TY - JOUR
T1 - Stem cell therapy for insulin-dependent diabetes
T2 - Are we still on the road?
AU - Yang, Lu
AU - Hu, Zhu Meng
AU - Jiang, Fang Xu
AU - Wang, Wei
PY - 2022
Y1 - 2022
N2 - In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore, the replacement of destroyed functional β cells with insulin-secreting cells derived from functional stem cells is a good idea as a new therapeutic idea. This review introduces the development schedule of mouse and human embryonic islets. The differences between mouse and human pancreas embryo development were also listed. Accordingly to the different sources of stem cells, the important research achievements on the differentiation of insulin-secreting β cells of stem cells and the current research status of stem cell therapy for diabetes were reviewed. Stem cell replacement therapy is a promising treatment for diabetes, caused by defective insulin secretion, but there are still many problems to be solved, such as the biosafety and reliability of treatment, the emergence of tumors during treatment, untargeted differentiation and autoimmunity, etc. Therefore, further understanding of stem cell therapy for insulin is needed.
AB - In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the patients must receive exogenous insulin to control blood sugar. However, there are still many deficiencies in exogenous insulin supplementation. Therefore, the replacement of destroyed functional β cells with insulin-secreting cells derived from functional stem cells is a good idea as a new therapeutic idea. This review introduces the development schedule of mouse and human embryonic islets. The differences between mouse and human pancreas embryo development were also listed. Accordingly to the different sources of stem cells, the important research achievements on the differentiation of insulin-secreting β cells of stem cells and the current research status of stem cell therapy for diabetes were reviewed. Stem cell replacement therapy is a promising treatment for diabetes, caused by defective insulin secretion, but there are still many problems to be solved, such as the biosafety and reliability of treatment, the emergence of tumors during treatment, untargeted differentiation and autoimmunity, etc. Therefore, further understanding of stem cell therapy for insulin is needed.
KW - Diabetes mellitus
KW - Differentiation
KW - Stem cell therapy
KW - Transplantation
KW - Β cell
UR - http://www.scopus.com/inward/record.url?scp=85135026986&partnerID=8YFLogxK
U2 - 10.4252/wjsc.v14.i7.503
DO - 10.4252/wjsc.v14.i7.503
M3 - Article
C2 - 36157527
AN - SCOPUS:85135026986
SN - 1948-0210
VL - 14
SP - 503
EP - 512
JO - World Journal of Stem Cells
JF - World Journal of Stem Cells
IS - 7
ER -