Statins may not protect against vasospasm in subarachnoid haemorrhage

M. Kern, May Lam, Neville Knuckey, Christopher Lind

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Statins have been shown in two recent small phase I/II trials to be associated with a marked reduction in clinical and transcranial Doppler (TCD) evidence of vasospasm after aneurysmal subarachnoid haemorrhage (SAH). The purpose of this study was to assess the clinical impact of this treatment in a larger number of patients. Fifty-eight individuals were treated in the year before, and 72 patients treated in the year after, the introduction of a 2 week course of 40 mg/day pravastatin therapy for SAH. Statins did not result in reduced TCD velocities, clinical or angiographic vasospasm, or improvements in global outcome at the time of hospital discharge. A measurable reduction in the rates of vasospasm was expected, based on the size of the effect of statin therapy in the previous small studies. There remains significant uncertainty as to the role of statins in preventing vasospasm after SAH.
Original languageEnglish
Pages (from-to)527-530
JournalJournal of Clinical Neuroscience
Volume16
Issue number4
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Statins may not protect against vasospasm in subarachnoid haemorrhage'. Together they form a unique fingerprint.

Cite this