Statins as potential antimalarial drugs : low relative potency and lack of synergy with conventional antimalarial drugs

R.P. Wong; Timothy Davis

doi:10.1128/AAC.01469-08

Statins as potential antimalarial drugs : low relative potency and lack of synergy with conventional antimalarial drugs

R.P. Wong, Timothy Davis

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of 17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.

Original language	English
Pages (from-to)	2212-2214
Journal	Antimicrobial Agents and Chemotherapy
Volume	53
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01469-08
Publication status	Published - 2009

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10.1128/AAC.01469-08

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title = "Statins as potential antimalarial drugs : low relative potency and lack of synergy with conventional antimalarial drugs",

abstract = "The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50\% inhibitory concentration of 17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.",

author = "R.P. Wong and Timothy Davis",

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AU - Wong, R.P.

AU - Davis, Timothy

PY - 2009

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N2 - The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of 17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.

AB - The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of 17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.

UR - https://www.scopus.com/pages/publications/66149139771

U2 - 10.1128/AAC.01469-08

DO - 10.1128/AAC.01469-08

M3 - Article

SN - 0066-4804

VL - 53

SP - 2212

EP - 2214

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Statins as potential antimalarial drugs : low relative potency and lack of synergy with conventional antimalarial drugs

Abstract

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