Statins as potential antimalarial drugs : low relative potency and lack of synergy with conventional antimalarial drugs

R.P. Wong, Timothy Davis

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of 17 µM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.
    Original languageEnglish
    Pages (from-to)2212-2214
    JournalAntimicrobial Agents and Chemotherapy
    Volume53
    Issue number5
    DOIs
    Publication statusPublished - 2009

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