TY - JOUR
T1 - Statin therapy and plasma coenzyme Q10 concentrations - A systematic review and meta-analysis of placebo-controlled trials
AU - Banach, M.
AU - Serban, C.
AU - Ursoniu, S.
AU - Rysz, J.
AU - Muntner, P.
AU - Toth, P.P.
AU - Jones, S.R.
AU - Rizzo, M.
AU - Glasser, S.P.
AU - Watts, Gerald
AU - Blumenthal, R.S.
AU - Lip, G.Y.H.
AU - Mikhailidis, D.P.
AU - Sahebkar, A.
PY - 2015
Y1 - 2015
N2 - © 2015 Published by Elsevier Ltd. Abstract Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is unclear. We assessed the impact of statin therapy on plasma CoQ10 concentrations through the meta-analysis of available RCTs. The literature search included selected databases up to April 30, 2015. The meta-analysis was performed using either a fixed-effects or random-effect model according to I2 statistic. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). The data from 8 placebo-controlled treatment arms suggested a significant reduction in plasma CoQ10 concentrations following treatment with statins (WMD: -0.44 μmol/L, 95%CI: -0.52, -0.37, p <0.001). The pooled effect size was robust and remained significant in the leave-one-out sensitivity analysis. Subgroup analysis suggested that the impact of statins on plasma CoQ10 concentrations is significant for all 4 types of statins studied i.e. atorvastatin (WMD: -0.41 μmol/L, 95%CI: -0.53, -0.29, p <0.001), simvastatin (WMD: -0.47 μmol/L, 95% CI: -0.61, -0.33, p <0.001), rosuvastatin (WMD: -0.49 μmol/L, 95%CI: -0.67, -0.31, p <0.001) and pravastatin (WMD: -0.43 μmol/L, 95%CI: -0.69, -0.16, p = 0.001). Likewise, there was no differential effect of lipophilic (WMD: -0.43 μmol/L, 95%CI: -0.53, -0.34, p <0.001) and hydrophilic statins (WMD: -0.47 μmol/L, 95%CI: -0.62, -0.32, p <0.001). With respect to treatment duration, a significant effect was observed in both subsets of trials lasting
AB - © 2015 Published by Elsevier Ltd. Abstract Statin therapy may lower plasma coenzyme Q10 (CoQ10) concentrations, but the evidence as to the significance of this effect is unclear. We assessed the impact of statin therapy on plasma CoQ10 concentrations through the meta-analysis of available RCTs. The literature search included selected databases up to April 30, 2015. The meta-analysis was performed using either a fixed-effects or random-effect model according to I2 statistic. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI). The data from 8 placebo-controlled treatment arms suggested a significant reduction in plasma CoQ10 concentrations following treatment with statins (WMD: -0.44 μmol/L, 95%CI: -0.52, -0.37, p <0.001). The pooled effect size was robust and remained significant in the leave-one-out sensitivity analysis. Subgroup analysis suggested that the impact of statins on plasma CoQ10 concentrations is significant for all 4 types of statins studied i.e. atorvastatin (WMD: -0.41 μmol/L, 95%CI: -0.53, -0.29, p <0.001), simvastatin (WMD: -0.47 μmol/L, 95% CI: -0.61, -0.33, p <0.001), rosuvastatin (WMD: -0.49 μmol/L, 95%CI: -0.67, -0.31, p <0.001) and pravastatin (WMD: -0.43 μmol/L, 95%CI: -0.69, -0.16, p = 0.001). Likewise, there was no differential effect of lipophilic (WMD: -0.43 μmol/L, 95%CI: -0.53, -0.34, p <0.001) and hydrophilic statins (WMD: -0.47 μmol/L, 95%CI: -0.62, -0.32, p <0.001). With respect to treatment duration, a significant effect was observed in both subsets of trials lasting
U2 - 10.1016/j.phrs.2015.07.008
DO - 10.1016/j.phrs.2015.07.008
M3 - Article
VL - 99
SP - 329
EP - 336
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -