Sponge (Porifera) Collagen for Bone Tissue Engineering

Minghao Zheng, Jessica Zheng

Research output: Chapter in Book/Conference paperChapterpeer-review

2 Citations (Scopus)

Abstract

t The ultimate goal of tissue engineering is to regenerate and/or replace fully functional tissue, or to stimulate the body to regenerate its own fully functional tissue (Vacanti and Langer in Lancet 354:SI32–SI34, 1999). This technology is of particular use in orthopaedics where various reconstructive operations are conducted
throughout the musculoskeletal system. Many tissue engineering techniques utilize
specific combinations of living cells, manufactured macromolecular biomaterials
(matrices), and bioactive factors (cytokines and/or growth factors) to direct synthesis and organization of tissues (Fodor in Reproductive Biology and Endocrinology 1:102, 2003). The architecture and biochemical nature of matrices is a key aspect of cell-based tissue engineering. The matrix provides a vehicle for delivery of stem cells and progenitors to a desired site, and provides surfaces that facilitate the attachment, survival, migration, proliferation and differentiation of these cells. The ideal
scaffold requirements for bone tissue engineering include biocompatibility, osteoconductive or osteoinductive capacity, high porosity that enables nutrient transport,
infiltration of cells, degradability over suitable time scales, and interstitial flow of fluid (Bruder and Fox in Clinical Orthopaedics and Related Research 367:S68–83,1999). The skeletons of Porifera appear to have unique properties that may provide for potential bioscaffolds in cell-based bone tissue engineering. These properties
include the collagenous composition of the fiber skeleton, its ability to hydrate to a high degree, and the possession of open interconnected channels created by the fiber network (Green et al. in Tissue Engineering 9:1159–1166, 2003). In addition to this, the phylum has a tremendous diversity of skeletal architecture within the 8000 extant species currently described, many of which are readily available for use (Hooper and Van Soest in Systema Porifera: a guide to the classification of sponges.
Original languageEnglish
Title of host publicationMarine-derived Biomaterials for Tissue Engineering Applications
EditorsAH Choi, B Ben-Nissan
Place of PublicationSingapore
PublisherSpringer Nature Singapore Pte Ltd
Chapter12
Pages247-283
Number of pages37
DOIs
Publication statusPublished - 2019

Publication series

NameSpringer Series in Biomaterials Science and Engineering
Volume14

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