TY - JOUR
T1 - Specific IgA, But Not IgG, in Human Milk From COVID-19-infected Mothers Neutralizes SARS-CoV-2
AU - Macchiaverni, Patricia
AU - Lloyd, Megan
AU - Masters, Laura
AU - Divakara, Nivedithaa
AU - Panta, Kritu
AU - Imrie, Allison
AU - Sánchez-García, Laura
AU - Pellicer, Adelina
AU - Rodriguez, Juan M
AU - Verhasselt, Valerie
N1 - Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.
AB - This study highlights the importance of human milk in providing anti-severe acute respiratory syndrome coronavirus 2 immunity to newborns. The highest protective activity of human milk against COVID-19 was found in colostrum from infected mothers. Neutralizing activity was associated with high levels of specific IgA. Depletion of IgA, but not IgG, from milk samples completely abolished the ability of human milk to neutralize severe acute respiratory syndrome coronavirus 2.
U2 - 10.1097/INF.0000000000004291
DO - 10.1097/INF.0000000000004291
M3 - Article
C2 - 38421196
SN - 0891-3668
VL - 43
SP - 532
EP - 535
JO - The Pediatric Infectious Disease Journal
JF - The Pediatric Infectious Disease Journal
IS - 6
ER -