Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy

Calyn Moulton

    Research output: ThesisDoctoral Thesis

    230 Downloads (Pure)

    Abstract

    Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date30 May 2017
    DOIs
    Publication statusUnpublished - 2017

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    Prostate
    Radiotherapy
    X-Rays
    New Zealand
    Prostatic Neoplasms
    Therapeutics

    Cite this

    @phdthesis{2da0fb9fb66b4b10a5a733102114455a,
    title = "Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy",
    abstract = "Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.",
    keywords = "Dose-surface maps, Prostate cancer, Deformable registration, Spatial dose analysis, Gastrointestinal toxicity, Accumulated dose, High-dose-rate brachytherapy, External beam radiotherapy",
    author = "Calyn Moulton",
    year = "2017",
    doi = "10.4225/23/5940e6be700d7",
    language = "English",
    school = "The University of Western Australia",

    }

    Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy. / Moulton, Calyn.

    2017.

    Research output: ThesisDoctoral Thesis

    TY - THES

    T1 - Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy

    AU - Moulton, Calyn

    PY - 2017

    Y1 - 2017

    N2 - Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.

    AB - Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.

    KW - Dose-surface maps

    KW - Prostate cancer

    KW - Deformable registration

    KW - Spatial dose analysis

    KW - Gastrointestinal toxicity

    KW - Accumulated dose

    KW - High-dose-rate brachytherapy

    KW - External beam radiotherapy

    U2 - 10.4225/23/5940e6be700d7

    DO - 10.4225/23/5940e6be700d7

    M3 - Doctoral Thesis

    ER -