Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy

Calyn Moulton

    Research output: ThesisDoctoral Thesis

    331 Downloads (Pure)

    Abstract

    Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date30 May 2017
    DOIs
    Publication statusUnpublished - 2017

    Fingerprint Dive into the research topics of 'Spatial dose-response models of rectal toxicities for patients undergoing prostate radiotherapy'. Together they form a unique fingerprint.

    Cite this