Prostate cancer can be treated with X-rays or X-rays followed by temporarily implanted radioactive sources. However, treatment is constrained by complications following undesirable rectal dose. This was the first study to accumulate rectal dose for the two phase treatment using deformable registration and then model how the distribution of rectal dose related to observed late rectal complications. Novel spatial features for mid-high dose regions were strongly associated with complications. The analysis for 891 patients from a large multi-centre trial undertaken across Australia and New Zealand indicated that novel spatial features may be useful for reducing complications in future treatments.
|Qualification||Doctor of Philosophy|
|Award date||30 May 2017|
|Publication status||Unpublished - 2017|