92 Citations (Scopus)


Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested. Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM. Crown Copyright (c) 2005 Published by Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)S109-S11
JournalLung Cancer
Issue numberSupp. 1
Publication statusPublished - 2005


Dive into the research topics of 'Soluble mesothelin-related protein - A blood test for mesothelioma'. Together they form a unique fingerprint.

Cite this