Soluble mesothelin-related protein - A blood test for mesothelioma

Research output: Contribution to journalArticle

83 Citations (Scopus)


Identification of tumor marker for mesothelioma (MM) might prove useful in diagnosis as well as for monitoring tumor in response to therapy and for screening at-risk individuals. We tested the hypothesis that soluble mesothelin-related protein (SMRP), a mesothelin family member, in the serum would be such a marker. Our data show that determination of SMRP in serum is a marker of MM with a sensitivity of sensitivity 83% and specificity 95% in the first 48 MM patients tested. Changes in serum SMRP levels parallel clinical course/tumor size and SMRP is elevated in 75% of patients at diagnosis. SMRP should also be useful for monitoring disease progression, and importantly, may prove useful for screening asbestos-exposed individuals for early MM. Crown Copyright (c) 2005 Published by Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)S109-S11
JournalLung Cancer
Issue numberSupp. 1
Publication statusPublished - 2005

Fingerprint Dive into the research topics of 'Soluble mesothelin-related protein - A blood test for mesothelioma'. Together they form a unique fingerprint.

Cite this