Abstract
This study investigated sleep subtypes in schizophrenia, and their response to Cognitive Behavioural Therapy for Insomnia (CBT-I) treatment. Sleep profiling was conducted using latent class analysis on baseline Pittsburgh Sleep Quality Index data (N = 74 outpatients with schizophrenia who were poor sleepers, 52% male, mean age = 41.4 years). Of these, 40 took part in CBT-I treatment. Analyses revealed three sleep subtypes based on total sleep time (TST), sleep efficiency (SE), and sleep onset latency (SOL) parameters: Cluster 1 (‘classic severe insomnia’ 44.6%), Cluster 2 (‘insomnia with normal sleep duration’ 37.8%), and Cluster 3 (‘insomnia with hypersomnia’ 17.6%). Gains analysis of pre- and post-treatment data from CBT-I participants revealed improvements in sleep and psychopathology in all three clusters, although there were some group differences in the areas and magnitude of improvement. Cluster 1 showed the greatest benefits with longer TST and improved SE. Cluster 2 showed a comparatively blunted treatment response although TST moved closer to recommended sleep guidelines. Cluster 3 showed significant reductions in TST. Altogether, this is the first demonstration of different sleep profiles in schizophrenia and their influence on treatment response to CBT-I. It also supports the notion that therapies should be tailored to the person and their insomnia presentation.
| Original language | English |
|---|---|
| Pages (from-to) | 279-287 |
| Number of pages | 9 |
| Journal | Psychiatry Research |
| Volume | 268 |
| DOIs | |
| Publication status | Published - 1 Oct 2018 |
Fingerprint
Cite this
}
Sleep profiles and CBT-I response in schizophrenia and related psychoses. / Chiu, Vivian W.; Ree, Melissa; Janca, Aleksandar; Iyyalol, Rajan; Dragovic, Milan; Waters, Flavie.
In: Psychiatry Research, Vol. 268, 01.10.2018, p. 279-287.Research output: Contribution to journal › Article
TY - JOUR
T1 - Sleep profiles and CBT-I response in schizophrenia and related psychoses
AU - Chiu, Vivian W.
AU - Ree, Melissa
AU - Janca, Aleksandar
AU - Iyyalol, Rajan
AU - Dragovic, Milan
AU - Waters, Flavie
PY - 2018/10/1
Y1 - 2018/10/1
N2 - This study investigated sleep subtypes in schizophrenia, and their response to Cognitive Behavioural Therapy for Insomnia (CBT-I) treatment. Sleep profiling was conducted using latent class analysis on baseline Pittsburgh Sleep Quality Index data (N = 74 outpatients with schizophrenia who were poor sleepers, 52% male, mean age = 41.4 years). Of these, 40 took part in CBT-I treatment. Analyses revealed three sleep subtypes based on total sleep time (TST), sleep efficiency (SE), and sleep onset latency (SOL) parameters: Cluster 1 (‘classic severe insomnia’ 44.6%), Cluster 2 (‘insomnia with normal sleep duration’ 37.8%), and Cluster 3 (‘insomnia with hypersomnia’ 17.6%). Gains analysis of pre- and post-treatment data from CBT-I participants revealed improvements in sleep and psychopathology in all three clusters, although there were some group differences in the areas and magnitude of improvement. Cluster 1 showed the greatest benefits with longer TST and improved SE. Cluster 2 showed a comparatively blunted treatment response although TST moved closer to recommended sleep guidelines. Cluster 3 showed significant reductions in TST. Altogether, this is the first demonstration of different sleep profiles in schizophrenia and their influence on treatment response to CBT-I. It also supports the notion that therapies should be tailored to the person and their insomnia presentation.
AB - This study investigated sleep subtypes in schizophrenia, and their response to Cognitive Behavioural Therapy for Insomnia (CBT-I) treatment. Sleep profiling was conducted using latent class analysis on baseline Pittsburgh Sleep Quality Index data (N = 74 outpatients with schizophrenia who were poor sleepers, 52% male, mean age = 41.4 years). Of these, 40 took part in CBT-I treatment. Analyses revealed three sleep subtypes based on total sleep time (TST), sleep efficiency (SE), and sleep onset latency (SOL) parameters: Cluster 1 (‘classic severe insomnia’ 44.6%), Cluster 2 (‘insomnia with normal sleep duration’ 37.8%), and Cluster 3 (‘insomnia with hypersomnia’ 17.6%). Gains analysis of pre- and post-treatment data from CBT-I participants revealed improvements in sleep and psychopathology in all three clusters, although there were some group differences in the areas and magnitude of improvement. Cluster 1 showed the greatest benefits with longer TST and improved SE. Cluster 2 showed a comparatively blunted treatment response although TST moved closer to recommended sleep guidelines. Cluster 3 showed significant reductions in TST. Altogether, this is the first demonstration of different sleep profiles in schizophrenia and their influence on treatment response to CBT-I. It also supports the notion that therapies should be tailored to the person and their insomnia presentation.
KW - Cognitive behavioural therapy
KW - Hypersomnia
KW - Insomnia
KW - Psychosis
KW - Schizophrenia
KW - Sleep duration
KW - Sleep profile
UR - http://www.scopus.com/inward/record.url?scp=85050891988&partnerID=8YFLogxK
U2 - 10.1016/j.psychres.2018.07.027
DO - 10.1016/j.psychres.2018.07.027
M3 - Article
VL - 268
SP - 279
EP - 287
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -