Skin tumor immunity: Site does matter for antigen presentation by DCs

Jason Waithman, T. Gebhardt, S. Bedoui

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The immune system has the ability to specifically identify and eliminate tumors, but the underlying mechanisms responsible for this phenomenon are not fully understood. A study published in this issue of the European Journal of Immunology now provides new insights into this important problem. Joncker et al. [Eur. J. Immunol. 2016. 46: 609-618] show that the timely mobilization of tumor antigen-bearing dendritic cells (DCs) from the periphery to the lymph nodes is critical for effective antitumor T-cell immunity, and that DCs present tumor antigens much more efficiently when encountered in the skin rather than in the subcutaneous tissues.
Original languageEnglish
Pages (from-to)543-546
JournalEuropean Journal of Immunology
Volume46
Issue number3
DOIs
Publication statusPublished - 2016

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