Skin biopsy in the diagnosis of inflammatory skin disease

Background Most non-neoplastic skin conditions are readily diagnosed by a combination of clinical history and examination, but in a small number of cases, biopsy for histopathology and other laboratory investigations can be invaluable tools. Close attention to communication of appropriate clinical details, selection of biopsy site and biopsy technique have a marked impact on the diagnostic yield of this procedure. Objectives The objectives of this article are to provide general principles related to the biopsy of non-neoplastic skin conditions and offer practical advice on the approach to some common skin conditions. Discussion In this article, we discuss a number of general principles that will ensure maximum benefits can be achieved when a biopsy is performed for the diagnosis of non-neoplastic skin disease. © The Royal Australian College of General Practitioners 2017.