Skeletal Muscle Involvement in Falciparum Malaria: Biochemical and Ultrastructural Study

Timothy Davis, E. Pongponratan, W. Supanaranond, S. Pukrittayakamee, T. Helliwell, P. Holloway, N.J. White

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    32 Citations (Scopus)


    Biochemical evidence of skeletal muscle damage is common in malaria, but rhabdomyolysis appears to be rare. To investigate the relationship between serum creatine kinase and myoglobin levels, muscle histology, and renal function in Plasmodium falciparum infections, we studied 13 patients with uncomplicated malaria, 13 with severe noncerebral malaria, and 10 with cerebral malaria. A muscle biopsy specimen was obtained from each patient for light microscopy and electron microscopy, Mean serum creatine kinase concentrations +/- SD were raised but similar for the three groups (258 +/- 277, 149 +/- 158, and 203 +/- 197 U/L, respectively; P =.5). The mean serum myoglobin level +/- SD was highest in cerebral malaria (457 +/- 246 vs. 170 +/- 150 and 209 +/- 125 ng/mL in uncomplicated and severe malaria, respectively; P
    Original languageEnglish
    Pages (from-to)831-835
    JournalClinical Infectious Diseases
    Publication statusPublished - 1999

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