Skeletal Muscle Involvement in Falciparum Malaria: Biochemical and Ultrastructural Study

Timothy Davis; E. Pongponratan; W. Supanaranond; S. Pukrittayakamee; T. Helliwell; P. Holloway; N.J. White

doi:10.1086/520444

Skeletal Muscle Involvement in Falciparum Malaria: Biochemical and Ultrastructural Study

Timothy Davis, E. Pongponratan, W. Supanaranond, S. Pukrittayakamee, T. Helliwell, P. Holloway, N.J. White

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Abstract

Biochemical evidence of skeletal muscle damage is common in malaria, but rhabdomyolysis appears to be rare. To investigate the relationship between serum creatine kinase and myoglobin levels, muscle histology, and renal function in Plasmodium falciparum infections, we studied 13 patients with uncomplicated malaria, 13 with severe noncerebral malaria, and 10 with cerebral malaria. A muscle biopsy specimen was obtained from each patient for light microscopy and electron microscopy, Mean serum creatine kinase concentrations +/- SD were raised but similar for the three groups (258 +/- 277, 149 +/- 158, and 203 +/- 197 U/L, respectively; P =.5). The mean serum myoglobin level +/- SD was highest in cerebral malaria (457 +/- 246 vs. 170 +/- 150 and 209 +/- 125 ng/mL in uncomplicated and severe malaria, respectively; P

Original language	English
Pages (from-to)	831-835
Journal	Clinical Infectious Diseases
Volume	29
DOIs	https://doi.org/10.1086/520444
Publication status	Published - 1999

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title = "Skeletal Muscle Involvement in Falciparum Malaria: Biochemical and Ultrastructural Study",

abstract = "Biochemical evidence of skeletal muscle damage is common in malaria, but rhabdomyolysis appears to be rare. To investigate the relationship between serum creatine kinase and myoglobin levels, muscle histology, and renal function in Plasmodium falciparum infections, we studied 13 patients with uncomplicated malaria, 13 with severe noncerebral malaria, and 10 with cerebral malaria. A muscle biopsy specimen was obtained from each patient for light microscopy and electron microscopy, Mean serum creatine kinase concentrations +/- SD were raised but similar for the three groups (258 +/- 277, 149 +/- 158, and 203 +/- 197 U/L, respectively; P =.5). The mean serum myoglobin level +/- SD was highest in cerebral malaria (457 +/- 246 vs. 170 +/- 150 and 209 +/- 125 ng/mL in uncomplicated and severe malaria, respectively; P",

author = "Timothy Davis and E. Pongponratan and W. Supanaranond and S. Pukrittayakamee and T. Helliwell and P. Holloway and N.J. White",

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AU - Davis, Timothy

AU - Pongponratan, E.

AU - Supanaranond, W.

AU - Pukrittayakamee, S.

AU - Helliwell, T.

AU - Holloway, P.

AU - White, N.J.

PY - 1999

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AB - Biochemical evidence of skeletal muscle damage is common in malaria, but rhabdomyolysis appears to be rare. To investigate the relationship between serum creatine kinase and myoglobin levels, muscle histology, and renal function in Plasmodium falciparum infections, we studied 13 patients with uncomplicated malaria, 13 with severe noncerebral malaria, and 10 with cerebral malaria. A muscle biopsy specimen was obtained from each patient for light microscopy and electron microscopy, Mean serum creatine kinase concentrations +/- SD were raised but similar for the three groups (258 +/- 277, 149 +/- 158, and 203 +/- 197 U/L, respectively; P =.5). The mean serum myoglobin level +/- SD was highest in cerebral malaria (457 +/- 246 vs. 170 +/- 150 and 209 +/- 125 ng/mL in uncomplicated and severe malaria, respectively; P

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