Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

M.S. Artigas, L.V. Wain, S. Miller, A.K. Kheirallah, J.E. Huffman, I. Ntalla, N. Shrine, M. Obeidat, H. Trochet, W.L. Mcardle, A.C. Alves, Jennie Hui, J.H. Zhao, P.K. Joshi, A. Teumer, E. Albrecht, M. Imboden, R. Rawal, L.M. Lopez, J. MartenS. Enroth, I. Surakka, O. Polasek, L.P. Lyytikäinen, R. Granell, P.G. Hysi, C. Flexeder, A. Mahajan, John Beilby, Y. Bossé, C.A. Brandsma, H. Campbell, C. Gieger, S. Gläser, J.R. González, H. Grallert, C.J. Hammond, S.E. Harris, A.L. Hartikainen, M. Heliövaara, J. Henderson, L. Hocking, M. Horikoshi, N. Hutri-Kähönen, E. Ingelsson, Å. Johansson, J.P. Kemp, I. Kolcic, A. Kumar, L. Lind, E. Melén, Arthur Musk, P. Navarro, D.C. Nickle, S. Padmanabhan, O.T. Raitakari, J.S. Ried, S. Ripatti, H. Schulz, R.A. Scott, D.D. Sin, J.M. Starr, A. Viñuela, H. Völzke, S.H. Wild, A.F. Wright, T. Zemunik, D.L. Jarvis, D.L. Spector, D.M. Evans, T. Lehtimäki, V. Vitart, M. Kähönen, U. Gyllensten, I. Rudan, I.J. Deary, S. Karrasch, N.M. Probst-Hensch, J. Heinrich, B. Stubbe, J.F. Wilson, N.J. Wareham, Alan James, A.P. Morris, M.-R. Jarvelin, C. Hayward, I. Sayers, D.P. Strachan, I.P. Hall, M.D. Tobin

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Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P
Original languageEnglish
Pages (from-to)Article 8658
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015

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