Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

M.S. Artigas; L.V. Wain; S. Miller; A.K. Kheirallah; J.E. Huffman; I. Ntalla; N. Shrine; M. Obeidat; H. Trochet; W.L. Mcardle; A.C. Alves; Jennie Hui; J.H. Zhao; P.K. Joshi; A. Teumer; E. Albrecht; M. Imboden; R. Rawal; L.M. Lopez; J. Marten; S. Enroth; I. Surakka; O. Polasek; L.P. Lyytikäinen; R. Granell; P.G. Hysi; C. Flexeder; A. Mahajan; John Beilby; Y. Bossé; C.A. Brandsma; H. Campbell; C. Gieger; S. Gläser; J.R. González; H. Grallert; C.J. Hammond; S.E. Harris; A.L. Hartikainen; M. Heliövaara; J. Henderson; L. Hocking; M. Horikoshi; N. Hutri-Kähönen; E. Ingelsson; Å. Johansson; J.P. Kemp; I. Kolcic; A. Kumar; L. Lind; E. Melén; Arthur Musk; P. Navarro; D.C. Nickle; S. Padmanabhan; O.T. Raitakari; J.S. Ried; S. Ripatti; H. Schulz; R.A. Scott; D.D. Sin; J.M. Starr; A. Viñuela; H. Völzke; S.H. Wild; A.F. Wright; T. Zemunik; D.L. Jarvis; D.L. Spector; D.M. Evans; T. Lehtimäki; V. Vitart; M. Kähönen; U. Gyllensten; I. Rudan; I.J. Deary; S. Karrasch; N.M. Probst-Hensch; J. Heinrich; B. Stubbe; J.F. Wilson; N.J. Wareham; Alan James; A.P. Morris; M.-R. Jarvelin; C. Hayward; I. Sayers; D.P. Strachan; I.P. Hall; M.D. Tobin

doi:10.1038/ncomms9658

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

M.S. Artigas, L.V. Wain, S. Miller, A.K. Kheirallah, J.E. Huffman, I. Ntalla, N. Shrine, M. Obeidat, H. Trochet, W.L. Mcardle, A.C. Alves, Jennie Hui, J.H. Zhao, P.K. Joshi, A. Teumer, E. Albrecht, M. Imboden, R. Rawal, L.M. Lopez, J. MartenS. Enroth, I. Surakka, O. Polasek, L.P. Lyytikäinen, R. Granell, P.G. Hysi, C. Flexeder, A. Mahajan, John Beilby, Y. Bossé, C.A. Brandsma, H. Campbell, C. Gieger, S. Gläser, J.R. González, H. Grallert, C.J. Hammond, S.E. Harris, A.L. Hartikainen, M. Heliövaara, J. Henderson, L. Hocking, M. Horikoshi, N. Hutri-Kähönen, E. Ingelsson, Å. Johansson, J.P. Kemp, I. Kolcic, A. Kumar, L. Lind, E. Melén, Arthur Musk, P. Navarro, D.C. Nickle, S. Padmanabhan, O.T. Raitakari, J.S. Ried, S. Ripatti, H. Schulz, R.A. Scott, D.D. Sin, J.M. Starr, A. Viñuela, H. Völzke, S.H. Wild, A.F. Wright, T. Zemunik, D.L. Jarvis, D.L. Spector, D.M. Evans, T. Lehtimäki, V. Vitart, M. Kähönen, U. Gyllensten, I. Rudan, I.J. Deary, S. Karrasch, N.M. Probst-Hensch, J. Heinrich, B. Stubbe, J.F. Wilson, N.J. Wareham, Alan James, A.P. Morris, M.-R. Jarvelin, C. Hayward, I. Sayers, D.P. Strachan, I.P. Hall, M.D. Tobin

Research output: Contribution to journal › Article › peer-review

93 Citations (Scopus)

Abstract

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

Original language	English
Pages (from-to)	Article 8658
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms9658
Publication status	Published - 2015

Access to Document

10.1038/ncomms9658

Cite this

Artigas, M. S., Wain, L. V., Miller, S., Kheirallah, A. K., Huffman, J. E., Ntalla, I., Shrine, N., Obeidat, M., Trochet, H., Mcardle, W. L., Alves, A. C., Hui, J., Zhao, J. H., Joshi, P. K., Teumer, A., Albrecht, E., Imboden, M., Rawal, R., Lopez, L. M., ... Tobin, M. D. (2015). Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, Article 8658. https://doi.org/10.1038/ncomms9658

@article{510d9c63db3b46d8a081c83085934cbb,

title = "Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation",

abstract = "Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P",

author = "M.S. Artigas and L.V. Wain and S. Miller and A.K. Kheirallah and J.E. Huffman and I. Ntalla and N. Shrine and M. Obeidat and H. Trochet and W.L. Mcardle and A.C. Alves and Jennie Hui and J.H. Zhao and P.K. Joshi and A. Teumer and E. Albrecht and M. Imboden and R. Rawal and L.M. Lopez and J. Marten and S. Enroth and I. Surakka and O. Polasek and L.P. Lyytik{\"a}inen and R. Granell and P.G. Hysi and C. Flexeder and A. Mahajan and John Beilby and Y. Boss{\'e} and C.A. Brandsma and H. Campbell and C. Gieger and S. Gl{\"a}ser and J.R. Gonz{\'a}lez and H. Grallert and C.J. Hammond and S.E. Harris and A.L. Hartikainen and M. Heli{\"o}vaara and J. Henderson and L. Hocking and M. Horikoshi and N. Hutri-K{\"a}h{\"o}nen and E. Ingelsson and {\AA}. Johansson and J.P. Kemp and I. Kolcic and A. Kumar and L. Lind and E. Mel{\'e}n and Arthur Musk and P. Navarro and D.C. Nickle and S. Padmanabhan and O.T. Raitakari and J.S. Ried and S. Ripatti and H. Schulz and R.A. Scott and D.D. Sin and J.M. Starr and A. Vi{\~n}uela and H. V{\"o}lzke and S.H. Wild and A.F. Wright and T. Zemunik and D.L. Jarvis and D.L. Spector and D.M. Evans and T. Lehtim{\"a}ki and V. Vitart and M. K{\"a}h{\"o}nen and U. Gyllensten and I. Rudan and I.J. Deary and S. Karrasch and N.M. Probst-Hensch and J. Heinrich and B. Stubbe and J.F. Wilson and N.J. Wareham and Alan James and A.P. Morris and M.-R. Jarvelin and C. Hayward and I. Sayers and D.P. Strachan and I.P. Hall and M.D. Tobin",

year = "2015",

doi = "10.1038/ncomms9658",

language = "English",

volume = "6",

pages = "Article 8658",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group - Macmillan Publishers",

}

Artigas, MS, Wain, LV, Miller, S, Kheirallah, AK, Huffman, JE, Ntalla, I, Shrine, N, Obeidat, M, Trochet, H, Mcardle, WL, Alves, AC, Hui, J, Zhao, JH, Joshi, PK, Teumer, A, Albrecht, E, Imboden, M, Rawal, R, Lopez, LM, Marten, J, Enroth, S, Surakka, I, Polasek, O, Lyytikäinen, LP, Granell, R, Hysi, PG, Flexeder, C, Mahajan, A, Beilby, J, Bossé, Y, Brandsma, CA, Campbell, H, Gieger, C, Gläser, S, González, JR, Grallert, H, Hammond, CJ, Harris, SE, Hartikainen, AL, Heliövaara, M, Henderson, J, Hocking, L, Horikoshi, M, Hutri-Kähönen, N, Ingelsson, E, Johansson, Å, Kemp, JP, Kolcic, I, Kumar, A, Lind, L, Melén, E, Musk, A, Navarro, P, Nickle, DC, Padmanabhan, S, Raitakari, OT, Ried, JS, Ripatti, S, Schulz, H, Scott, RA, Sin, DD, Starr, JM, Viñuela, A, Völzke, H, Wild, SH, Wright, AF, Zemunik, T, Jarvis, DL, Spector, DL, Evans, DM, Lehtimäki, T, Vitart, V, Kähönen, M, Gyllensten, U, Rudan, I, Deary, IJ, Karrasch, S, Probst-Hensch, NM, Heinrich, J, Stubbe, B, Wilson, JF, Wareham, NJ, James, A, Morris, AP, Jarvelin, M-R, Hayward, C, Sayers, I, Strachan, DP, Hall, IP & Tobin, MD 2015, 'Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation', Nature Communications, vol. 6, pp. Article 8658. https://doi.org/10.1038/ncomms9658

TY - JOUR

T1 - Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

AU - Artigas, M.S.

AU - Wain, L.V.

AU - Miller, S.

AU - Kheirallah, A.K.

AU - Huffman, J.E.

AU - Ntalla, I.

AU - Shrine, N.

AU - Obeidat, M.

AU - Trochet, H.

AU - Mcardle, W.L.

AU - Alves, A.C.

AU - Hui, Jennie

AU - Zhao, J.H.

AU - Joshi, P.K.

AU - Teumer, A.

AU - Albrecht, E.

AU - Imboden, M.

AU - Rawal, R.

AU - Lopez, L.M.

AU - Marten, J.

AU - Enroth, S.

AU - Surakka, I.

AU - Polasek, O.

AU - Lyytikäinen, L.P.

AU - Granell, R.

AU - Hysi, P.G.

AU - Flexeder, C.

AU - Mahajan, A.

AU - Beilby, John

AU - Bossé, Y.

AU - Brandsma, C.A.

AU - Campbell, H.

AU - Gieger, C.

AU - Gläser, S.

AU - González, J.R.

AU - Grallert, H.

AU - Hammond, C.J.

AU - Harris, S.E.

AU - Hartikainen, A.L.

AU - Heliövaara, M.

AU - Henderson, J.

AU - Hocking, L.

AU - Horikoshi, M.

AU - Hutri-Kähönen, N.

AU - Ingelsson, E.

AU - Johansson, Å.

AU - Kemp, J.P.

AU - Kolcic, I.

AU - Kumar, A.

AU - Lind, L.

AU - Melén, E.

AU - Musk, Arthur

AU - Navarro, P.

AU - Nickle, D.C.

AU - Padmanabhan, S.

AU - Raitakari, O.T.

AU - Ried, J.S.

AU - Ripatti, S.

AU - Schulz, H.

AU - Scott, R.A.

AU - Sin, D.D.

AU - Starr, J.M.

AU - Viñuela, A.

AU - Völzke, H.

AU - Wild, S.H.

AU - Wright, A.F.

AU - Zemunik, T.

AU - Jarvis, D.L.

AU - Spector, D.L.

AU - Evans, D.M.

AU - Lehtimäki, T.

AU - Vitart, V.

AU - Kähönen, M.

AU - Gyllensten, U.

AU - Rudan, I.

AU - Deary, I.J.

AU - Karrasch, S.

AU - Probst-Hensch, N.M.

AU - Heinrich, J.

AU - Stubbe, B.

AU - Wilson, J.F.

AU - Wareham, N.J.

AU - James, Alan

AU - Morris, A.P.

AU - Jarvelin, M.-R.

AU - Hayward, C.

AU - Sayers, I.

AU - Strachan, D.P.

AU - Hall, I.P.

AU - Tobin, M.D.

PY - 2015

Y1 - 2015

N2 - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

AB - Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P

U2 - 10.1038/ncomms9658

DO - 10.1038/ncomms9658

M3 - Article

C2 - 26635082

SN - 2041-1723

VL - 6

SP - Article 8658

JO - Nature Communications

JF - Nature Communications

ER -

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Abstract

Access to Document

Fingerprint

Cite this