Single-stage object detector with attention mechanism for squamous cell carcinoma feature detection using histopathological images

Squamous cell carcinoma is the most common type of cancer that occurs in squamous cells of epithelial tissue. Histopathological evaluation of tissue samples is the gold standard approach used for carcinoma diagnosis. SCC detection based on various histopathological features often employs traditional machine learning approaches or pixel-based deep CNN models. This study aims to detect keratin pearl, the most prominent SCC feature, by implementing RetinaNet one-stage object detector. Further, we enhance the model performance by incorporating an attention module. The proposed method is more efficient in detection of small keratin pearls. This is the first work detecting keratin pearl resorting to the object detection technique to the extent of our knowledge. We conducted a comprehensive assessment of the model both quantitatively and qualitatively. The experimental results demonstrate that the proposed approach enhanced the mAP by about 4% compared to default RetinaNet model.