Abstract
Background: In children with cystic fibrosis (CF) lung clearance index (LCI) from multiple-breath washout (MBW) correlates with structural lung disease. As a shorter test, single-breath washout (SBW) represents an attractive alternative to assess the ventilation distribution, however, data for the correlation with lung imaging are lacking. Methods: We assessed correlations between phase III slope (SIII) of double-tracer gas SBW, nitrogen MBW indices (LCI and moment ratios for overall ventilation distribution, Scond, and Sacin for conductive and mainly acinar ventilation, respectively) and structural lung disease assessed by chest computed tomography (CT) in children with CF. Results: In a prospective cross-sectional study data from MBW, SBW, and chest CT were obtained in 32 children with CF with a median (range) age of 8.2 (5.2-16.3) years. Bronchiectasis was present in 24 (75%) children and air trapping was present in 29 (91%). Median (IQR) SIII of SBW was −138.4 (150.6) mg/mol. We found no association between SIII with either the MBW outcomes or CT scores (n = 23, association with bronchiectasis extent r = 0.10, P = 0.64). LCI and Scond were associated with bronchiectasis extent (n = 23, r = 0.57, P = 0.004; r = 0.60, P = 0.003, respectively). Conclusions: Acinar ventilation inhomogeneity measured by SBW was not associated with structural lung disease on CT. Double-tracer SBW added no benefit to indices measured by MBW.
| Original language | English |
|---|---|
| Pages (from-to) | 587-594 |
| Number of pages | 8 |
| Journal | Pediatric Pulmonology |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2019 |
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Single-breath washout and association with structural lung disease in children with cystic fibrosis. / Yammine, Sophie; Ramsey, Kathryn A.; Skoric, Billy; King, Louise; Latzin, Philipp; Rosenow, Tim; Hall, Graham L.; Ranganathan, Sarath C.
In: Pediatric Pulmonology, Vol. 54, No. 5, 01.05.2019, p. 587-594.Research output: Contribution to journal › Article
TY - JOUR
T1 - Single-breath washout and association with structural lung disease in children with cystic fibrosis
AU - Yammine, Sophie
AU - Ramsey, Kathryn A.
AU - Skoric, Billy
AU - King, Louise
AU - Latzin, Philipp
AU - Rosenow, Tim
AU - Hall, Graham L.
AU - Ranganathan, Sarath C.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Background: In children with cystic fibrosis (CF) lung clearance index (LCI) from multiple-breath washout (MBW) correlates with structural lung disease. As a shorter test, single-breath washout (SBW) represents an attractive alternative to assess the ventilation distribution, however, data for the correlation with lung imaging are lacking. Methods: We assessed correlations between phase III slope (SIII) of double-tracer gas SBW, nitrogen MBW indices (LCI and moment ratios for overall ventilation distribution, Scond, and Sacin for conductive and mainly acinar ventilation, respectively) and structural lung disease assessed by chest computed tomography (CT) in children with CF. Results: In a prospective cross-sectional study data from MBW, SBW, and chest CT were obtained in 32 children with CF with a median (range) age of 8.2 (5.2-16.3) years. Bronchiectasis was present in 24 (75%) children and air trapping was present in 29 (91%). Median (IQR) SIII of SBW was −138.4 (150.6) mg/mol. We found no association between SIII with either the MBW outcomes or CT scores (n = 23, association with bronchiectasis extent r = 0.10, P = 0.64). LCI and Scond were associated with bronchiectasis extent (n = 23, r = 0.57, P = 0.004; r = 0.60, P = 0.003, respectively). Conclusions: Acinar ventilation inhomogeneity measured by SBW was not associated with structural lung disease on CT. Double-tracer SBW added no benefit to indices measured by MBW.
AB - Background: In children with cystic fibrosis (CF) lung clearance index (LCI) from multiple-breath washout (MBW) correlates with structural lung disease. As a shorter test, single-breath washout (SBW) represents an attractive alternative to assess the ventilation distribution, however, data for the correlation with lung imaging are lacking. Methods: We assessed correlations between phase III slope (SIII) of double-tracer gas SBW, nitrogen MBW indices (LCI and moment ratios for overall ventilation distribution, Scond, and Sacin for conductive and mainly acinar ventilation, respectively) and structural lung disease assessed by chest computed tomography (CT) in children with CF. Results: In a prospective cross-sectional study data from MBW, SBW, and chest CT were obtained in 32 children with CF with a median (range) age of 8.2 (5.2-16.3) years. Bronchiectasis was present in 24 (75%) children and air trapping was present in 29 (91%). Median (IQR) SIII of SBW was −138.4 (150.6) mg/mol. We found no association between SIII with either the MBW outcomes or CT scores (n = 23, association with bronchiectasis extent r = 0.10, P = 0.64). LCI and Scond were associated with bronchiectasis extent (n = 23, r = 0.57, P = 0.004; r = 0.60, P = 0.003, respectively). Conclusions: Acinar ventilation inhomogeneity measured by SBW was not associated with structural lung disease on CT. Double-tracer SBW added no benefit to indices measured by MBW.
KW - cystic fibrosis
KW - lung function
KW - lung imaging
KW - single-breath washout
UR - http://www.scopus.com/inward/record.url?scp=85061583463&partnerID=8YFLogxK
U2 - 10.1002/ppul.24271
DO - 10.1002/ppul.24271
M3 - Article
VL - 54
SP - 587
EP - 594
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
SN - 1099-0496
IS - 5
ER -