Simulating platelet transport in Type-B aortic dissection

Louis P. Parker, Lachlan J. Kelsey, James Mallal, Roland Hustinx, Natzi Sakalihasan, Paul E. Norman, Barry Doyle

Research output: Chapter in Book/Conference paperChapter

Abstract

Abstract Aortic dissection is where the medial layer of the arterial wall is separated by a tear leading to intramural bleeding. The blood forms an alternate channel of flow known as the false lumen. Thrombosis of the false lumen (FL) is common in cases of dissection as flow conditions are typically more stagnant than in the true lumen (TL). Central to the process of thrombosis is the activation and aggregation of platelets in the blood. Therefore, the aim of this work is to simulate the transport of platelets in a case of Type-B aortic dissection in a clinically-relevant timeframe. We investigated a 38-year-old female with Type-B aortic dissection. After reconstructing the contrast-enhanced computed tomography (CT) scans into three dimensions, we created a computational mesh of polyhedral and prismelements. We used realistic boundary conditions at the inlet and at the outlets via 3-element Windkessel models. A one-way Lagrangian method was used to model the trajectories of platelets and particles were injected for 11 s over 16 cardiac cycles. The total number of injected particles was 1.5M. We ran our simulations on 512 cores of the MAGNUS supercomputer at the Pawsey Supercomputing Centre. We observed elevated residence times of these particles in regions of both stagnant (low TAWSS) and recirculating flow (high OSI), emphasising the need to consider both TAWSS and OSI in thrombus susceptibility predictions for dissection. Tear geometry was seen to have a dominating effect on TL haemodynamics, with platelets colliding and adhering to the wall primarily around the proximal entry tears and supra-aortic branching vessels. The complex flow patterns support the need for computational modelling to reveal flow conditions and prognosis for Type-B aortic dissection patients. Furthermore, high-performance computing enables computationally expensive patient- specific simulations to be carried out within a clinical timescale.

Original languageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
EditorsPoul M Nielsen, Adam Wittek, Karol Miller, Barry Doyle, Grand R. Joldes, Maryn P. Nash
Place of PublicationSwitzerland
PublisherSpringer International Publishing AG
Pages145-159
Number of pages15
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018

Fingerprint

Dissection
dissection
Platelets
platelets
lumens
Blood Platelets
Tears
thrombosis
Thrombosis
blood
Blood
Computing Methodologies
Patient Simulation
bleeding
supercomputers
hemodynamics
prognosis
Supercomputers
Platelet Activation
Hemodynamics

Cite this

Parker, L. P., Kelsey, L. J., Mallal, J., Hustinx, R., Sakalihasan, N., Norman, P. E., & Doyle, B. (2018). Simulating platelet transport in Type-B aortic dissection. In P. M. Nielsen, A. Wittek, K. Miller, B. Doyle, G. R. Joldes, & M. P. Nash (Eds.), Computational Biomechanics for Medicine: Measurements, Models, and Predictions (pp. 145-159). Switzerland: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-75589-2_14
Parker, Louis P. ; Kelsey, Lachlan J. ; Mallal, James ; Hustinx, Roland ; Sakalihasan, Natzi ; Norman, Paul E. ; Doyle, Barry. / Simulating platelet transport in Type-B aortic dissection. Computational Biomechanics for Medicine: Measurements, Models, and Predictions. editor / Poul M Nielsen ; Adam Wittek ; Karol Miller ; Barry Doyle ; Grand R. Joldes ; Maryn P. Nash. Switzerland : Springer International Publishing AG, 2018. pp. 145-159
@inbook{7466cd0fd0274003bfe41a2526001854,
title = "Simulating platelet transport in Type-B aortic dissection",
abstract = "Abstract Aortic dissection is where the medial layer of the arterial wall is separated by a tear leading to intramural bleeding. The blood forms an alternate channel of flow known as the false lumen. Thrombosis of the false lumen (FL) is common in cases of dissection as flow conditions are typically more stagnant than in the true lumen (TL). Central to the process of thrombosis is the activation and aggregation of platelets in the blood. Therefore, the aim of this work is to simulate the transport of platelets in a case of Type-B aortic dissection in a clinically-relevant timeframe. We investigated a 38-year-old female with Type-B aortic dissection. After reconstructing the contrast-enhanced computed tomography (CT) scans into three dimensions, we created a computational mesh of polyhedral and prismelements. We used realistic boundary conditions at the inlet and at the outlets via 3-element Windkessel models. A one-way Lagrangian method was used to model the trajectories of platelets and particles were injected for 11 s over 16 cardiac cycles. The total number of injected particles was 1.5M. We ran our simulations on 512 cores of the MAGNUS supercomputer at the Pawsey Supercomputing Centre. We observed elevated residence times of these particles in regions of both stagnant (low TAWSS) and recirculating flow (high OSI), emphasising the need to consider both TAWSS and OSI in thrombus susceptibility predictions for dissection. Tear geometry was seen to have a dominating effect on TL haemodynamics, with platelets colliding and adhering to the wall primarily around the proximal entry tears and supra-aortic branching vessels. The complex flow patterns support the need for computational modelling to reveal flow conditions and prognosis for Type-B aortic dissection patients. Furthermore, high-performance computing enables computationally expensive patient- specific simulations to be carried out within a clinical timescale.",
author = "Parker, {Louis P.} and Kelsey, {Lachlan J.} and James Mallal and Roland Hustinx and Natzi Sakalihasan and Norman, {Paul E.} and Barry Doyle",
year = "2018",
month = "5",
day = "14",
doi = "10.1007/978-3-319-75589-2_14",
language = "English",
isbn = "9783319755885",
pages = "145--159",
editor = "Nielsen, {Poul M} and Adam Wittek and Karol Miller and Barry Doyle and Joldes, {Grand R. } and Nash, {Maryn P.}",
booktitle = "Computational Biomechanics for Medicine",
publisher = "Springer International Publishing AG",
address = "Switzerland",

}

Parker, LP, Kelsey, LJ, Mallal, J, Hustinx, R, Sakalihasan, N, Norman, PE & Doyle, B 2018, Simulating platelet transport in Type-B aortic dissection. in PM Nielsen, A Wittek, K Miller, B Doyle, GR Joldes & MP Nash (eds), Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Springer International Publishing AG, Switzerland, pp. 145-159. https://doi.org/10.1007/978-3-319-75589-2_14

Simulating platelet transport in Type-B aortic dissection. / Parker, Louis P.; Kelsey, Lachlan J.; Mallal, James; Hustinx, Roland; Sakalihasan, Natzi; Norman, Paul E.; Doyle, Barry.

Computational Biomechanics for Medicine: Measurements, Models, and Predictions. ed. / Poul M Nielsen; Adam Wittek; Karol Miller; Barry Doyle; Grand R. Joldes; Maryn P. Nash. Switzerland : Springer International Publishing AG, 2018. p. 145-159.

Research output: Chapter in Book/Conference paperChapter

TY - CHAP

T1 - Simulating platelet transport in Type-B aortic dissection

AU - Parker, Louis P.

AU - Kelsey, Lachlan J.

AU - Mallal, James

AU - Hustinx, Roland

AU - Sakalihasan, Natzi

AU - Norman, Paul E.

AU - Doyle, Barry

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Abstract Aortic dissection is where the medial layer of the arterial wall is separated by a tear leading to intramural bleeding. The blood forms an alternate channel of flow known as the false lumen. Thrombosis of the false lumen (FL) is common in cases of dissection as flow conditions are typically more stagnant than in the true lumen (TL). Central to the process of thrombosis is the activation and aggregation of platelets in the blood. Therefore, the aim of this work is to simulate the transport of platelets in a case of Type-B aortic dissection in a clinically-relevant timeframe. We investigated a 38-year-old female with Type-B aortic dissection. After reconstructing the contrast-enhanced computed tomography (CT) scans into three dimensions, we created a computational mesh of polyhedral and prismelements. We used realistic boundary conditions at the inlet and at the outlets via 3-element Windkessel models. A one-way Lagrangian method was used to model the trajectories of platelets and particles were injected for 11 s over 16 cardiac cycles. The total number of injected particles was 1.5M. We ran our simulations on 512 cores of the MAGNUS supercomputer at the Pawsey Supercomputing Centre. We observed elevated residence times of these particles in regions of both stagnant (low TAWSS) and recirculating flow (high OSI), emphasising the need to consider both TAWSS and OSI in thrombus susceptibility predictions for dissection. Tear geometry was seen to have a dominating effect on TL haemodynamics, with platelets colliding and adhering to the wall primarily around the proximal entry tears and supra-aortic branching vessels. The complex flow patterns support the need for computational modelling to reveal flow conditions and prognosis for Type-B aortic dissection patients. Furthermore, high-performance computing enables computationally expensive patient- specific simulations to be carried out within a clinical timescale.

AB - Abstract Aortic dissection is where the medial layer of the arterial wall is separated by a tear leading to intramural bleeding. The blood forms an alternate channel of flow known as the false lumen. Thrombosis of the false lumen (FL) is common in cases of dissection as flow conditions are typically more stagnant than in the true lumen (TL). Central to the process of thrombosis is the activation and aggregation of platelets in the blood. Therefore, the aim of this work is to simulate the transport of platelets in a case of Type-B aortic dissection in a clinically-relevant timeframe. We investigated a 38-year-old female with Type-B aortic dissection. After reconstructing the contrast-enhanced computed tomography (CT) scans into three dimensions, we created a computational mesh of polyhedral and prismelements. We used realistic boundary conditions at the inlet and at the outlets via 3-element Windkessel models. A one-way Lagrangian method was used to model the trajectories of platelets and particles were injected for 11 s over 16 cardiac cycles. The total number of injected particles was 1.5M. We ran our simulations on 512 cores of the MAGNUS supercomputer at the Pawsey Supercomputing Centre. We observed elevated residence times of these particles in regions of both stagnant (low TAWSS) and recirculating flow (high OSI), emphasising the need to consider both TAWSS and OSI in thrombus susceptibility predictions for dissection. Tear geometry was seen to have a dominating effect on TL haemodynamics, with platelets colliding and adhering to the wall primarily around the proximal entry tears and supra-aortic branching vessels. The complex flow patterns support the need for computational modelling to reveal flow conditions and prognosis for Type-B aortic dissection patients. Furthermore, high-performance computing enables computationally expensive patient- specific simulations to be carried out within a clinical timescale.

UR - http://www.scopus.com/inward/record.url?scp=85053544088&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-75589-2_14

DO - 10.1007/978-3-319-75589-2_14

M3 - Chapter

SN - 9783319755885

SP - 145

EP - 159

BT - Computational Biomechanics for Medicine

A2 - Nielsen, Poul M

A2 - Wittek, Adam

A2 - Miller, Karol

A2 - Doyle, Barry

A2 - Joldes, Grand R.

A2 - Nash, Maryn P.

PB - Springer International Publishing AG

CY - Switzerland

ER -

Parker LP, Kelsey LJ, Mallal J, Hustinx R, Sakalihasan N, Norman PE et al. Simulating platelet transport in Type-B aortic dissection. In Nielsen PM, Wittek A, Miller K, Doyle B, Joldes GR, Nash MP, editors, Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Switzerland: Springer International Publishing AG. 2018. p. 145-159 https://doi.org/10.1007/978-3-319-75589-2_14