Signal transduction and neurosurvival in experimental models of brain injury

T. L. Butler; C. A. Kassed; K. R. Pennypacker

doi:10.1016/S0361-9230(02)00926-7

Signal transduction and neurosurvival in experimental models of brain injury

T. L. Butler, C. A. Kassed, K. R. Pennypacker

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

Original language	English
Pages (from-to)	339-351
Number of pages	13
Journal	Brain Research Bulletin
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/S0361-9230(02)00926-7
Publication status	Published - 30 Jan 2003
Externally published	Yes

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10.1016/S0361-9230(02)00926-7

Cite this

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abstract = "Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.",

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AU - Kassed, C. A.

AU - Pennypacker, K. R.

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N2 - Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

AB - Brain injury and neurodegenerative disease are linked by their primary pathological consequence - death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed.

KW - Animal model

KW - AP-1

KW - Growth factor

KW - Neuron

KW - NF-κB

KW - Signaling pathways

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JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

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ER -

Signal transduction and neurosurvival in experimental models of brain injury

Abstract

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