Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature

Research output: Contribution to journalArticle

Abstract

We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature in vivo based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused by blood flow result in higher values of the average magnitude in the frequency domain compared to those from static tissue. Weighting of the signal by the inverse of the zero-frequency component (i.e., the sum of the OCT signal time series) improves vessel contrast in flow regions of low OCT signal. The method is demonstrated on a fabricated flow phantom and on human skin in vivo and, at only 5 time points per voxel, shows enhanced vessel contrast in comparison to conventional correlation mapping/speckle decorrelation and speckle variance methods. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Original languageEnglish
Pages (from-to)293-307
Number of pages15
JournalBiomedical Optics Express
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Cite this

@article{dbe3ea868f08479eb85a5c2ffb217436,
title = "Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature",
abstract = "We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature in vivo based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused by blood flow result in higher values of the average magnitude in the frequency domain compared to those from static tissue. Weighting of the signal by the inverse of the zero-frequency component (i.e., the sum of the OCT signal time series) improves vessel contrast in flow regions of low OCT signal. The method is demonstrated on a fabricated flow phantom and on human skin in vivo and, at only 5 time points per voxel, shows enhanced vessel contrast in comparison to conventional correlation mapping/speckle decorrelation and speckle variance methods. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement",
keywords = "AMPLITUDE-DECORRELATION, CORONARY-ANGIOGRAPHY, SPECKLE-VARIANCE, OCT ANGIOGRAPHY, HUMAN SKIN, MICROCIRCULATION, INTENSITY, VISUALIZATION, VASCULATURE, MORPHOLOGY",
author = "Qiang Wang and Peijun Gong and Barry Cense and Sampson, {David D.}",
year = "2019",
month = "1",
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doi = "10.1364/BOE.10.000293",
language = "English",
volume = "10",
pages = "293--307",
journal = "Biomedical Optics Express",
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TY - JOUR

T1 - Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature

AU - Wang, Qiang

AU - Gong, Peijun

AU - Cense, Barry

AU - Sampson, David D.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature in vivo based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused by blood flow result in higher values of the average magnitude in the frequency domain compared to those from static tissue. Weighting of the signal by the inverse of the zero-frequency component (i.e., the sum of the OCT signal time series) improves vessel contrast in flow regions of low OCT signal. The method is demonstrated on a fabricated flow phantom and on human skin in vivo and, at only 5 time points per voxel, shows enhanced vessel contrast in comparison to conventional correlation mapping/speckle decorrelation and speckle variance methods. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

AB - We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature in vivo based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused by blood flow result in higher values of the average magnitude in the frequency domain compared to those from static tissue. Weighting of the signal by the inverse of the zero-frequency component (i.e., the sum of the OCT signal time series) improves vessel contrast in flow regions of low OCT signal. The method is demonstrated on a fabricated flow phantom and on human skin in vivo and, at only 5 time points per voxel, shows enhanced vessel contrast in comparison to conventional correlation mapping/speckle decorrelation and speckle variance methods. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

KW - AMPLITUDE-DECORRELATION

KW - CORONARY-ANGIOGRAPHY

KW - SPECKLE-VARIANCE

KW - OCT ANGIOGRAPHY

KW - HUMAN SKIN

KW - MICROCIRCULATION

KW - INTENSITY

KW - VISUALIZATION

KW - VASCULATURE

KW - MORPHOLOGY

U2 - 10.1364/BOE.10.000293

DO - 10.1364/BOE.10.000293

M3 - Article

VL - 10

SP - 293

EP - 307

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 1

ER -