Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome

Stephanie Trend, Anderson P. Jones, Lilian Cha, Matthew N. Cooper, Sian Geldenhuys, Marzena J. Fabis-Pedrini, William M. Carroll, Judith M. Cole, David R. Booth, Robyn M. Lucas, Martyn A. French, Scott N. Byrne, Allan G. Kermode, Prue H. Hart

Research output: Contribution to journalArticle

Abstract

Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naive B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.

Original languageEnglish
Article number7980
Number of pages13
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 28 May 2019

Cite this

@article{fd1906a2ec9d4901b67053c9c45686a6,
title = "Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome",
abstract = "Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naive B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.",
keywords = "REGULATORY B-CELLS, MULTIPLE-SCLEROSIS, ULTRAVIOLET-B, BONE-MARROW, T-CELLS, MEMORY, LIGHT, IRRADIATION, SUPPRESSION, ACTIVATION",
author = "Stephanie Trend and Jones, {Anderson P.} and Lilian Cha and Cooper, {Matthew N.} and Sian Geldenhuys and Fabis-Pedrini, {Marzena J.} and Carroll, {William M.} and Cole, {Judith M.} and Booth, {David R.} and Lucas, {Robyn M.} and French, {Martyn A.} and Byrne, {Scott N.} and Kermode, {Allan G.} and Hart, {Prue H.}",
year = "2019",
month = "5",
day = "28",
doi = "10.1038/s41598-019-44488-6",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "1",

}

Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome. / Trend, Stephanie; Jones, Anderson P.; Cha, Lilian; Cooper, Matthew N.; Geldenhuys, Sian; Fabis-Pedrini, Marzena J.; Carroll, William M.; Cole, Judith M.; Booth, David R.; Lucas, Robyn M.; French, Martyn A.; Byrne, Scott N.; Kermode, Allan G.; Hart, Prue H.

In: Scientific Reports, Vol. 9, No. 1, 7980, 28.05.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Short-term changes in frequencies of circulating leukocytes associated with narrowband UVB phototherapy in people with clinically isolated syndrome

AU - Trend, Stephanie

AU - Jones, Anderson P.

AU - Cha, Lilian

AU - Cooper, Matthew N.

AU - Geldenhuys, Sian

AU - Fabis-Pedrini, Marzena J.

AU - Carroll, William M.

AU - Cole, Judith M.

AU - Booth, David R.

AU - Lucas, Robyn M.

AU - French, Martyn A.

AU - Byrne, Scott N.

AU - Kermode, Allan G.

AU - Hart, Prue H.

PY - 2019/5/28

Y1 - 2019/5/28

N2 - Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naive B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.

AB - Clinically isolated syndrome (CIS) is the earliest clinical episode in multiple sclerosis (MS). Low environmental exposure to UV radiation is implicated in risk of developing MS, and therefore, narrowband UVB phototherapy might delay progression to MS in people with CIS. Twenty individuals with CIS were recruited, and half were randomised to receive 24 sessions of narrowband UVB phototherapy over a period of 8 weeks. Here, the effects of narrowband UVB phototherapy on the frequencies of circulating immune cells and immunoglobulin levels after phototherapy are reported. Peripheral blood samples for all participants were collected at baseline, and 1, 2, 3, 6 and 12 months after enrolment. An extensive panel of leukocyte populations, including subsets of T cells, B cells, monocytes, dendritic cells, and natural killer cells were examined in phototherapy-treated and control participants, and immunoglobulin levels measured in serum. There were significant short-term increases in the frequency of naive B cells, intermediate monocytes, and fraction III FoxP3+ T regulatory cells, and decreases in switched memory B cells and classical monocytes in phototherapy-treated individuals. Since B cells are increasingly targeted by MS therapies, the effects of narrowband UVB phototherapy in people with MS should be investigated further.

KW - REGULATORY B-CELLS

KW - MULTIPLE-SCLEROSIS

KW - ULTRAVIOLET-B

KW - BONE-MARROW

KW - T-CELLS

KW - MEMORY

KW - LIGHT

KW - IRRADIATION

KW - SUPPRESSION

KW - ACTIVATION

U2 - 10.1038/s41598-019-44488-6

DO - 10.1038/s41598-019-44488-6

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7980

ER -