Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

KT Batty, Peter Gibbons, Timothy Davis, [No Value] Tme, Kenneth Ilett

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 Uhr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.
Original languageEnglish
Pages (from-to)641-642
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume78
Issue number4
DOIs
Publication statusPublished - 2008

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