Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

KT Batty; Peter Gibbons; Timothy Davis; [No Value] Tme; Kenneth Ilett

doi:10.4269/ajtmh.2010.09-0470

Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

KT Batty, Peter Gibbons, Timothy Davis, [No Value] Tme, Kenneth Ilett

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Abstract

Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 Uhr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.

Original language	English
Pages (from-to)	641-642
Journal	American Journal of Tropical Medicine and Hygiene
Volume	78
Issue number	4
DOIs	https://doi.org/10.4269/ajtmh.2010.09-0470
Publication status	Published - 2008

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10.4269/ajtmh.2010.09-0470

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title = "Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model",

abstract = "Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 Uhr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.",

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AU - Gibbons, Peter

AU - Davis, Timothy

AU - Tme, [No Value]

AU - Ilett, Kenneth

PY - 2008

Y1 - 2008

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AB - Pharmacokinetic properties of dihydroartemisinin (DHA) were determined in mice given 100 mg/kg intraperitoneal DHA. Half-life, CL/F, and V/F were 25 min, 61.3 L/hr/kg, and 36.3 L/kg in malaria-infected mice and 19 min, 50.9 Uhr/kg, and 23.0 L/kg in controls. These data are valuable for pharmacokinetic-pharmacodynamic evaluations of DHA in murine models.

U2 - 10.4269/ajtmh.2010.09-0470

DO - 10.4269/ajtmh.2010.09-0470

M3 - Article

C2 - 20133997

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SP - 641

EP - 642

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

IS - 4

ER -

Short report: Pharmacokinetics of dihydroartemisinin in a murine malaria model

Abstract

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