Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy

M. Stephanie, Y.G. Susufi, E. Krisnuhoni, R.A. Gani, E. Yunihastuti, S. Lee, Sara Tanaskovic, P. Price

    Research output: Contribution to journalArticle

    Abstract

    © Copyright 2016, Mary Ann Liebert, Inc. 2016.Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4+ and CD8+ cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.
    Original languageEnglish
    Pages (from-to)1202-1204
    JournalAIDS Research and Human Retroviruses
    Volume32
    Issue number12
    DOIs
    Publication statusPublished - 2016

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    Communication
    HIV
    Liver
    Indonesia
    Therapeutics
    Coinfection
    Hepacivirus
    Immune System
    Cell Count
    T-Lymphocytes

    Cite this

    Stephanie, M., Susufi, Y. G., Krisnuhoni, E., Gani, R. A., Yunihastuti, E., Lee, S., ... Price, P. (2016). Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. AIDS Research and Human Retroviruses, 32(12), 1202-1204. https://doi.org/10.1089/aid.2016.0042
    Stephanie, M. ; Susufi, Y.G. ; Krisnuhoni, E. ; Gani, R.A. ; Yunihastuti, E. ; Lee, S. ; Tanaskovic, Sara ; Price, P. / Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. In: AIDS Research and Human Retroviruses. 2016 ; Vol. 32, No. 12. pp. 1202-1204.
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    abstract = "{\circledC} Copyright 2016, Mary Ann Liebert, Inc. 2016.Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4+ and CD8+ cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.",
    author = "M. Stephanie and Y.G. Susufi and E. Krisnuhoni and R.A. Gani and E. Yunihastuti and S. Lee and Sara Tanaskovic and P. Price",
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    Stephanie, M, Susufi, YG, Krisnuhoni, E, Gani, RA, Yunihastuti, E, Lee, S, Tanaskovic, S & Price, P 2016, 'Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy' AIDS Research and Human Retroviruses, vol. 32, no. 12, pp. 1202-1204. https://doi.org/10.1089/aid.2016.0042

    Short Communication: Few Liver-Infiltrating Cells Express CXCR3 in HIV/HCV Patients Commencing Antiretroviral Therapy. / Stephanie, M.; Susufi, Y.G.; Krisnuhoni, E.; Gani, R.A.; Yunihastuti, E.; Lee, S.; Tanaskovic, Sara; Price, P.

    In: AIDS Research and Human Retroviruses, Vol. 32, No. 12, 2016, p. 1202-1204.

    Research output: Contribution to journalArticle

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    AU - Stephanie, M.

    AU - Susufi, Y.G.

    AU - Krisnuhoni, E.

    AU - Gani, R.A.

    AU - Yunihastuti, E.

    AU - Lee, S.

    AU - Tanaskovic, Sara

    AU - Price, P.

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    N2 - © Copyright 2016, Mary Ann Liebert, Inc. 2016.Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4+ and CD8+ cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.

    AB - © Copyright 2016, Mary Ann Liebert, Inc. 2016.Coinfections with Hepatitis C virus and human immunodeficiency virus accelerate the progression of both conditions and hamper effective treatment. Here we describe expression of CXCR3 on liver-infiltrating cells and peripheral T cells from coinfected patients commencing antiretroviral therapy (ART) in Indonesia. CXCR3 was expressed by small number of intrahepatic inflammatory cells, mostly in the portal areas. The number of cells did not change on ART and was markedly lower than the number of CD4+ and CD8+ cells in the liver. Data suggest that CXCR3 may contribute to liver infiltration but demonstrate a dynamic situation, changing as the immune system recovers on ART.

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