Shifting the limits in wheat research and breeding using a fully annotated reference genome

International Wheat Genome Sequencing Consortium (IWGSC)

doi:10.1126/science.aar7191

Shifting the limits in wheat research and breeding using a fully annotated reference genome

International Wheat Genome Sequencing Consortium (IWGSC)

Research output: Contribution to journal › Article › peer-review

2333 Citations (Scopus)

Abstract

An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

Original language	English
Article number	eaar7191
Journal	Science
Volume	361
Issue number	6403
DOIs	https://doi.org/10.1126/science.aar7191
Publication status	Published - 17 Aug 2018

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10.1126/science.aar7191

http://pure-oai.bham.ac.uk/ws/files/54477981/IWGSC_RefSeqv1.0.pdf

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@article{8883a580b33c4558b37f291af8c61c84,

title = "Shifting the limits in wheat research and breeding using a fully annotated reference genome",

abstract = "An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.",

author = "{International Wheat Genome Sequencing Consortium (IWGSC)} and Rudi Appels and Kellye Eversole and Catherine Feuillet and Beat Keller and Jane Rogers and Nils Stein and Pozniak, {Curtis J} and Fr{\'e}d{\'e}ric Choulet and Assaf Distelfeld and Kellye Eversole and Jesse Poland and Jane Rogers and Gil Ronen and Sharpe, {Andrew G} and Curtis Pozniak and Gil Ronen and Omer Barad and Kobi Baruch and Gabriel Keeble-Gagn{\`e}re and Martin Mascher and Gil Ben-Zvi and Ambre-Aurore Josselin and Axel Himmelbach and Jane Rogers and Fran{\c c}ois Balfourier and Juan Gutierrez-Gonzalez and Matthew Hayden and ChuShin Koh and Gary Muehlbauer and Pasam, {Raj K} and Etienne Paux and Pozniak, {Curtis J} and Philippe Rigault and Josquin Tibbits and Vijay Tiwari and Jane Rogers and Manuel Spannagl and Daniel Lang and Heidrun Gundlach and Georg Haberer and Mayer, {Klaus F X} and Danara Ormanbekova and Etienne Paux and Verena Prade and Hana {\v S}imkov{\'a} and Thomas Wicker and Manuel Spannagl and David Swarbreck and H{\'e}l{\`e}ne Rimbert and Marius Felder and Nicolas Guilhot and Heidrun Gundlach and Georg Haberer and Gemy Kaithakottil and Jens Keilwagen and Daniel Lang and Philippe Leroy and Thomas Lux and Mayer, {Klaus F X} and Sven Twardziok and Luca Venturini and H{\'e}l{\`e}ne Rimbert and Ang{\'e}la Juh{\'a}sz and Manuel Spannagl and Daniel Lang and Michael Abrouk and Georg Haberer and Mayer, {Klaus F X} and Thomas Wicker and Thomas Wicker and Heidrun Gundlach and Daniel Lang and Manuel Spannagl and Daniel Lang and Manuel Spannagl and Iris Fischer and Cristobal Uauy and Philippa Borrill and Ramirez-Gonzalez, {Ricardo H} and Dominique Arnaud and Smahane Chalabi and Boulos Chalhoub and Aron Cory and Raju Datla and Davey, {Mark W} and John Jacobs and Daniel Lang and Robinson, {Stephen J} and Manuel Spannagl and Burkhard Steuernagel and Vijay Tiwari and {van Ex}, Fred and Wulff, {Brande B H} and Pozniak, {Curtis J} and Aron Cory and Moussa Benhamed and Etienne Paux and Abdelhafid Bendahmane and Lorenzo Concia and David Latrasse and Jane Rogers and John Jacobs and Michael Alaux and Jan Barto{\v s} and Arnaud Bellec and H{\'e}l{\`e}ne Berges and Jaroslav Dole{\v z}el and Catherine Feuillet and Zeev Frenkel and Bikram Gill and Abraham Korol and Thomas Letellier and Odd-Arne Olsen and Kuldeep Singh and Miroslav Val{\'a}rik and {van der Vossen}, Edwin and Sonia Vautrin and Song Weining and Abraham Korol and Zeev Frenkel and Tzion Fahima and Vladimir Glikson and Dina Raats and Jane Rogers and Vijay Tiwari and Bikram Gill and Etienne Paux and Jesse Poland and Jarmila {\v C}{\'i}hal{\'i}kov{\'a} and Helena Toegelov{\'a} and Jan Vr{\'a}na and Pierre Sourdille and Benoit Darrier and Manuel Spannagl and Daniel Lang and Iris Fischer and Danara Ormanbekova and Verena Prade and Delfina Barabaschi and Luigi Cattivelli and Pilar Hernandez and Sergio Galvez and Hikmet Budak and Jones, {Jonathan D G} and Kamil Witek and Guotai Yu and Ian Small and Joanna Melonek and Ruonan Zhou and Ang{\'e}la Juh{\'a}sz and Tatiana Belova and Odd-Arne Olsen and Kostya Kanyuka and Robert King and Kirby Nilsen and Sean Walkowiak and Pozniak, {Curtis J} and Richard Cuthbert and Raju Datla and Ron Knox and Krysta Wiebe and Daoquan Xiang and Antje Rohde and Timothy Golds and Jana {\v C}{\'i}{\v z}kov{\'a} and Hikmet Budak and Akpinar, {Bala Ani} and Sezgi Biyiklioglu and Gary Muehlbauer and Jesse Poland and Liangliang Gao and Amidou N'Daiye and Marie Kubal{\'a}kov{\'a} and Jan {\v S}af{\'a}{\v r} and Jan Vr{\'a}na and H{\'e}l{\`e}ne Berges and Arnaud Bellec and Sonia Vautrin and Michael Alaux and Fran{\c c}oise Alfama and Anne-Fran{\c c}oise Adam-Blondon and Raphael Flores and Claire Guerche and Thomas Letellier and Mika{\"e}l Loaec and Hadi Quesneville and Pozniak, {Curtis J} and Sean Walkowiak and Hikmet Budak and Janet Condie and Jennifer Ens and ChuShin Koh and Ron Maclachlan and Jianzhong Wu and Jacqueline Batley and Bayer, {Philipp E} and David Edwards and Le Wang",

note = "Copyright {\textcopyright} 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2018",

month = aug,

day = "17",

doi = "10.1126/science.aar7191",

language = "English",

volume = "361",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "6403",

}

TY - JOUR

T1 - Shifting the limits in wheat research and breeding using a fully annotated reference genome

AU - International Wheat Genome Sequencing Consortium (IWGSC)

AU - Appels, Rudi

AU - Eversole, Kellye

AU - Feuillet, Catherine

AU - Keller, Beat

AU - Rogers, Jane

AU - Stein, Nils

AU - Pozniak, Curtis J

AU - Choulet, Frédéric

AU - Distelfeld, Assaf

AU - Eversole, Kellye

AU - Poland, Jesse

AU - Rogers, Jane

AU - Ronen, Gil

AU - Sharpe, Andrew G

AU - Pozniak, Curtis

AU - Ronen, Gil

AU - Barad, Omer

AU - Baruch, Kobi

AU - Keeble-Gagnère, Gabriel

AU - Mascher, Martin

AU - Ben-Zvi, Gil

AU - Josselin, Ambre-Aurore

AU - Himmelbach, Axel

AU - Rogers, Jane

AU - Balfourier, François

AU - Gutierrez-Gonzalez, Juan

AU - Hayden, Matthew

AU - Koh, ChuShin

AU - Muehlbauer, Gary

AU - Pasam, Raj K

AU - Paux, Etienne

AU - Pozniak, Curtis J

AU - Rigault, Philippe

AU - Tibbits, Josquin

AU - Tiwari, Vijay

AU - Rogers, Jane

AU - Spannagl, Manuel

AU - Lang, Daniel

AU - Gundlach, Heidrun

AU - Haberer, Georg

AU - Mayer, Klaus F X

AU - Ormanbekova, Danara

AU - Paux, Etienne

AU - Prade, Verena

AU - Šimková, Hana

AU - Wicker, Thomas

AU - Spannagl, Manuel

AU - Swarbreck, David

AU - Rimbert, Hélène

AU - Felder, Marius

AU - Guilhot, Nicolas

AU - Gundlach, Heidrun

AU - Haberer, Georg

AU - Kaithakottil, Gemy

AU - Keilwagen, Jens

AU - Lang, Daniel

AU - Leroy, Philippe

AU - Lux, Thomas

AU - Mayer, Klaus F X

AU - Twardziok, Sven

AU - Venturini, Luca

AU - Rimbert, Hélène

AU - Juhász, Angéla

AU - Spannagl, Manuel

AU - Lang, Daniel

AU - Abrouk, Michael

AU - Haberer, Georg

AU - Mayer, Klaus F X

AU - Wicker, Thomas

AU - Gundlach, Heidrun

AU - Lang, Daniel

AU - Spannagl, Manuel

AU - Lang, Daniel

AU - Spannagl, Manuel

AU - Fischer, Iris

AU - Uauy, Cristobal

AU - Borrill, Philippa

AU - Ramirez-Gonzalez, Ricardo H

AU - Arnaud, Dominique

AU - Chalabi, Smahane

AU - Chalhoub, Boulos

AU - Cory, Aron

AU - Datla, Raju

AU - Davey, Mark W

AU - Jacobs, John

AU - Lang, Daniel

AU - Robinson, Stephen J

AU - Spannagl, Manuel

AU - Steuernagel, Burkhard

AU - Tiwari, Vijay

AU - van Ex, Fred

AU - Wulff, Brande B H

AU - Pozniak, Curtis J

AU - Cory, Aron

AU - Benhamed, Moussa

AU - Paux, Etienne

AU - Bendahmane, Abdelhafid

AU - Concia, Lorenzo

AU - Latrasse, David

AU - Rogers, Jane

AU - Jacobs, John

AU - Alaux, Michael

AU - Bartoš, Jan

AU - Bellec, Arnaud

AU - Berges, Hélène

AU - Doležel, Jaroslav

AU - Feuillet, Catherine

AU - Frenkel, Zeev

AU - Gill, Bikram

AU - Korol, Abraham

AU - Letellier, Thomas

AU - Olsen, Odd-Arne

AU - Singh, Kuldeep

AU - Valárik, Miroslav

AU - van der Vossen, Edwin

AU - Vautrin, Sonia

AU - Weining, Song

AU - Korol, Abraham

AU - Frenkel, Zeev

AU - Fahima, Tzion

AU - Glikson, Vladimir

AU - Raats, Dina

AU - Rogers, Jane

AU - Tiwari, Vijay

AU - Gill, Bikram

AU - Paux, Etienne

AU - Poland, Jesse

AU - Číhalíková, Jarmila

AU - Toegelová, Helena

AU - Vrána, Jan

AU - Sourdille, Pierre

AU - Darrier, Benoit

AU - Spannagl, Manuel

AU - Lang, Daniel

AU - Fischer, Iris

AU - Ormanbekova, Danara

AU - Prade, Verena

AU - Barabaschi, Delfina

AU - Cattivelli, Luigi

AU - Hernandez, Pilar

AU - Galvez, Sergio

AU - Budak, Hikmet

AU - Jones, Jonathan D G

AU - Witek, Kamil

AU - Yu, Guotai

AU - Small, Ian

AU - Melonek, Joanna

AU - Zhou, Ruonan

AU - Juhász, Angéla

AU - Belova, Tatiana

AU - Olsen, Odd-Arne

AU - Kanyuka, Kostya

AU - King, Robert

AU - Nilsen, Kirby

AU - Walkowiak, Sean

AU - Pozniak, Curtis J

AU - Cuthbert, Richard

AU - Datla, Raju

AU - Knox, Ron

AU - Wiebe, Krysta

AU - Xiang, Daoquan

AU - Rohde, Antje

AU - Golds, Timothy

AU - Čížková, Jana

AU - Budak, Hikmet

AU - Akpinar, Bala Ani

AU - Biyiklioglu, Sezgi

AU - Muehlbauer, Gary

AU - Poland, Jesse

AU - Gao, Liangliang

AU - N'Daiye, Amidou

AU - Kubaláková, Marie

AU - Šafář, Jan

AU - Vrána, Jan

AU - Berges, Hélène

AU - Bellec, Arnaud

AU - Vautrin, Sonia

AU - Alaux, Michael

AU - Alfama, Françoise

AU - Adam-Blondon, Anne-Françoise

AU - Flores, Raphael

AU - Guerche, Claire

AU - Letellier, Thomas

AU - Loaec, Mikaël

AU - Quesneville, Hadi

AU - Pozniak, Curtis J

AU - Walkowiak, Sean

AU - Budak, Hikmet

AU - Condie, Janet

AU - Ens, Jennifer

AU - Koh, ChuShin

AU - Maclachlan, Ron

AU - Wu, Jianzhong

AU - Batley, Jacqueline

AU - Bayer, Philipp E

AU - Edwards, David

AU - Wang, Le

PY - 2018/8/17

Y1 - 2018/8/17

N2 - An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

AB - An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

U2 - 10.1126/science.aar7191

DO - 10.1126/science.aar7191

M3 - Article

C2 - 30115783

SN - 0036-8075

VL - 361

JO - Science

JF - Science

IS - 6403

M1 - eaar7191

ER -

Shifting the limits in wheat research and breeding using a fully annotated reference genome

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