Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?

Lieke W J van den Elsen, Johan Garssen, Remy Burcelin, Valerie Verhasselt

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the "window of opportunity" in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention.

Original languageEnglish
Article number47
JournalFrontiers in Pediatrics
Volume7
DOIs
Publication statusPublished - 27 Feb 2019

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Breast Feeding
Hypersensitivity
Milk
Secretory Immunoglobulin A
Microbiota
Human Milk
Oligosaccharides
Gastrointestinal Microbiome
Mothers
Health
Growth

Cite this

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title = "Shaping the Gut Microbiota by Breastfeeding: The Gateway to Allergy Prevention?",
abstract = "Evidence is accumulating that demonstrates the importance of the gut microbiota in health and diseases such as allergy. Recent studies emphasize the importance of the {"}window of opportunity{"} in early life, during which interventions altering the gut microbiota induce long-term effects. The neonate's gut microbiota composition and metabolism could therefore play an essential role in allergic disease risk. Breastfeeding shapes the gut microbiota in early life, both directly by exposure of the neonate to the milk microbiota and indirectly, via maternal milk factors that affect bacterial growth and metabolism such as human milk oligosaccharides, secretory IgA, and anti-microbial factors. The potential of breastmilk to modulate the offspring's early gut microbiota is a promising tool for allergy prevention. Here, we will review the existing evidence demonstrating the impact of breastfeeding on shaping the neonate's gut microbiota and highlight the potential of this strategy for allergy prevention.",
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Shaping the Gut Microbiota by Breastfeeding : The Gateway to Allergy Prevention? / van den Elsen, Lieke W J; Garssen, Johan; Burcelin, Remy; Verhasselt, Valerie.

In: Frontiers in Pediatrics, Vol. 7, 47, 27.02.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Shaping the Gut Microbiota by Breastfeeding

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AU - van den Elsen, Lieke W J

AU - Garssen, Johan

AU - Burcelin, Remy

AU - Verhasselt, Valerie

PY - 2019/2/27

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