Sex-related Risk of Cardiovascular Events Following Hospitalisation for Chronic Coronary Disease

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Abstract

Background
There is an increasing clinical focus on chronic coronary disease (CCD), yet population-level data on outcomes in CCD patients are limited. Our aim was to describe characteristics of people hospitalised with CCD and measure the short and long-term risk of cardiovascular outcomes by sex.

Method
We used state-wide linked hospitalisation/mortality data to identify CCD patients based on first (index) hospitalisation for stable angina (SA; ICD-10-AM I20.1–I20.9) or chronic ischaemic heart disease (IHD; I25) in 2002–2017. Kaplan-Meier survival analyses were used to estimate risk of acute coronary syndrome (ACS) and CVD death during 15-years follow-up from the linked dataset.

Results
There were 32,696 index SA (38% female) and 29,365 index chronic IHD (27% female) cases, with overall mean age of 66 years in men and 69 years in women in both groups. Men admitted with SA were more likely to receive angiography+/-revascularisation compared to women (66% vs 50% respectively, p<0.0001); but there was no difference between men and women for chronic IHD admissions (94% men, 91% women). One- and 15-year risk of ACS was greater in SA than chronic IHD patients, with minimal difference by sex (Table). Risk of CVD mortality was 1.4% at 1-year in SA and chronic IHD patients, increasing to 13.7% in men and 14.5% women at 15 years.

Conclusion
There is a high short- and long-term risk of ACS or CVD death after index CCD hospitalisation irrespective of sex, indicating need for improved clinical management and secondary prevention of CCD in both sexes.
Original languageEnglish
Pages (from-to)S370-S371
JournalHeart, Lung and Circulation
Volume32
Issue numberS3
DOIs
Publication statusPublished - Jul 2023

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