@article{399b5ce7233c49b4aa97f22d8dc2f6c8,
title = "Sex differences in oncogenic mutational processes",
abstract = "Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.",
author = "{PCAWG Tumour Subtypes and Clinical Translation} and {PCAWG Consortium} and Li, {Constance H.} and Prokopec, {Stephenie D.} and Sun, {Ren X.} and Fouad Yousif and Nathaniel Schmitz and Fatima Al-Shahrour and Gurnit Atwal and Bailey, {Peter J.} and Biankin, {Andrew V.} and Boutros, {Paul C.} and Campbell, {Peter J.} and Chang, {David K.} and Cooke, {Susanna L.} and Vikram Deshpande and Faltas, {Bishoy M.} and Faquin, {William C.} and Levi Garraway and Gad Getz and Grimmond, {Sean M.} and Syed Haider and Hoadley, {Katherine A.} and Wei Jiao and Kaiser, {Vera B.} and Rosa Karli{\'c} and Mamoru Kato and Kirsten K{\"u}bler and Lazar, {Alexander J.} and Li, {Constance H.} and Louis, {David N.} and Adam Margolin and Sancha Martin and Nahal-Bose, {Hardeep K.} and Nielsen, {G. Petur} and Serena Nik-Zainal and Larsson Omberg and Christine P{\textquoteright}ng and Perry, {Marc D.} and Paz Polak and Esther Rheinbay and Rubin, {Mark A.} and Semple, {Colin A.} and Sgroi, {Dennis C.} and Tatsuhiro Shibata and Reiner Siebert and Jaclyn Smith and Stein, {Lincoln D.} and Stobbe, {Miranda D.} and Sun, {Ren X.} and Kevin Thai and Wright, {Derek W.} and Wu, {Chin Lee} and Ke Yuan and Junjun Zhang and Boutros, {Paul C.} and Aaltonen, {Lauri A.} and Federico Abascal and Adam Abeshouse and Hiroyuki Aburatani and Adams, {David J.} and Nishant Agrawal and Ahn, {Keun Soo} and Ahn, {Sung Min} and Hiroshi Aikata and Rehan Akbani and Akdemir, {Kadir C.} and Hikmat Al-Ahmadie and Al-Sedairy, {Sultan T.} and Fatima Al-Shahrour and Malik Alawi and Monique Albert and Kenneth Aldape and Alexandrov, {Ludmil B.} and Adrian Ally and Kathryn Alsop and Alvarez, {Eva G.} and Fernanda Amary and Amin, {Samirkumar B.} and Brice Aminou and Ole Ammerpohl and Anderson, {Matthew J.} and Yeng Ang and Davide Antonello and Pavana Anur and Samuel Aparicio and Appelbaum, {Elizabeth L.} and Yasuhito Arai and Axel Aretz and Koji Arihiro and Ariizumi, {Shun ichi} and Joshua Armenia and Laurent Arnould and Sylvia Asa and Yassen Assenov and Gurnit Atwal and Sietse Aukema and Auman, {J. Todd} and Aure, {Miriam R.} and Philip Awadalla and Marta Aymerich and Bader, {Gary D.} and Adrian Baez-Ortega and Bailey, {Matthew H.} and Bailey, {Peter J.} and Miruna Balasundaram and Saianand Balu and Pratiti Bandopadhayay and Banks, {Rosamonde E.} and Stefano Barbi and Barbour, {Andrew P.} and Jonathan Barenboim and Jill Barnholtz-Sloan and Hugh Barr and Elisabet Barrera and John Bartlett and Javier Bartolome and Claudio Bassi and Bathe, {Oliver F.} and Daniel Baumhoer and Prashant Bavi and Baylin, {Stephen B.} and Wojciech Bazant and Duncan Beardsmore and Beck, {Timothy A.} and Sam Behjati and Andreas Behren and Beifang Niu and Cindy Bell and Sergi Beltran and Christopher Benz and Andrew Berchuck and Bergmann, {Anke K.} and Bergstrom, {Erik N.} and Berman, {Benjamin P.} and Berney, {Daniel M.} and Bernhart, {Stephan H.} and Rameen Beroukhim and Mario Berrios and Samantha Bersani and Johanna Bertl and Miguel Betancourt and Vinayak Bhandari and Bhosle, {Shriram G.} and Biankin, {Andrew V.} and Matthias Bieg and Darell Bigner and Hans Binder and Ewan Birney and Michael Birrer and Biswas, {Nidhan K.} and Bodil Bjerkehagen and Tom Bodenheimer and Lori Boice and Giada Bonizzato and {De Bono}, {Johann S.} and Arnoud Boot and Bootwalla, {Moiz S.} and Ake Borg and Arndt Borkhardt and Boroevich, {Keith A.} and Ivan Borozan and Christoph Borst and Marcus Bosenberg and Mattia Bosio and Jacqueline Boultwood and Guillaume Bourque and Boutros, {Paul C.} and Bova, {G. Steven} and Bowen, {David T.} and Reanne Bowlby and Bowtell, {David D.L.} and Sandrine Boyault and Rich Boyce and Jeffrey Boyd and Alvis Brazma and Paul Brennan and Brewer, {Daniel S.} and Brinkman, {Arie B.} and Bristow, {Robert G.} and Broaddus, {Russell R.} and Brock, {Jane E.} and Malcolm Brock and Annegien Broeks and Brooks, {Angela N.} and Denise Brooks and Benedikt Brors and S{\o}ren Brunak and Bruxner, {Timothy J.C.} and Bruzos, {Alicia L.} and Alex Buchanan and Ivo Buchhalter and Christiane Buchholz and Susan Bullman and Hazel Burke and Birgit Burkhardt and Burns, {Kathleen H.} and John Busanovich and Bustamante, {Carlos D.} and Butler, {Adam P.} and Butte, {Atul J.} and Byrne, {Niall J.} and B{\o}rresen-Dale, {Anne Lise} and Caesar-Johnson, {Samantha J.} and Andy Cafferkey and Declan Cahill and Claudia Calabrese and Carlos Caldas and Fabien Calvo and Niedzica Camacho and Elias Campo and Cinzia Cant{\`u} and Shaolong Cao and Carey, {Thomas E.} and Joana Carlevaro-Fita and Rebecca Carlsen and Ivana Cataldo and Mario Cazzola and Jonathan Cebon and Robert Cerfolio and Chadwick, {Dianne E.} and Dimple Chakravarty and Don Chalmers and Chan, {Calvin Wing Yiu} and Kin Chan and Michelle Chan-Seng-Yue and Chandan, {Vishal S.} and Chang, {David K.} and Chanock, {Stephen J.} and Chantrill, {Lorraine A.} and Aur{\'e}lien Chateigner and Nilanjan Chatterjee and Kazuaki Chayama and Chen, {Hsiao Wei} and Jieming Chen and Ken Chen and Holt, {Robert A.} and Yi Huang and Jones, {David R.} and Jones, {David R.} and Li, {Haiyan Irene} and Lin Li and Miller, {David K.} and Chris Mitchell and Simpson, {Peter T.} and Thompson, {John F.} and Jian Wang and Waring, {Paul M.} and Yang Yang and Nikolajs Zeps and Fan Zhang",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41467-020-17359-2",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "1",
}
