Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women

Kristyn A. Bates, Hamid R. Sohrabi, Stephanie R. Rainey-Smith, Michael Weinborn, Romola S. Bucks, Mark Rodrigues, John Beilby, Matthew Howard, Kevin Taddei, Georgia Martins, Athena Paton, Tejal Shah, Satvinder S. Dhaliwal, Jonathan K. Foster, Ian J. Martins, Nicola T. Lautenschlager, Frank L. Mastaglia, Samuel E. Gandy, Ralph N. Martins

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p

Original languageEnglish
Pages (from-to)243-252
Number of pages10
JournalInternational Journal of Neuroscience
Issue number3
Publication statusPublished - 4 Mar 2017


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