Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women

Kristyn A. Bates; Hamid R. Sohrabi; Stephanie R. Rainey-Smith; Michael Weinborn; Romola S. Bucks; Mark Rodrigues; John Beilby; Matthew Howard; Kevin Taddei; Georgia Martins; Athena Paton; Tejal Shah; Satvinder S. Dhaliwal; Jonathan K. Foster; Ian J. Martins; Nicola T. Lautenschlager; Frank L. Mastaglia; Samuel E. Gandy; Ralph N. Martins

doi:10.1080/00207454.2016.1182527

Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women

Kristyn A. Bates, Hamid R. Sohrabi, Stephanie R. Rainey-Smith, Michael Weinborn, Romola S. Bucks, Mark Rodrigues, John Beilby, Matthew Howard, Kevin Taddei, Georgia Martins, Athena Paton, Tejal Shah, Satvinder S. Dhaliwal, Jonathan K. Foster, Ian J. Martins, Nicola T. Lautenschlager, Frank L. Mastaglia, Samuel E. Gandy, Ralph N. Martins

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p

Original language	English
Pages (from-to)	243-252
Number of pages	10
Journal	International Journal of Neuroscience
Volume	127
Issue number	3
DOIs	https://doi.org/10.1080/00207454.2016.1182527
Publication status	Published - 4 Mar 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/00207454.2016.1182527

Cite this

Bates, K. A., Sohrabi, H. R., Rainey-Smith, S. R., Weinborn, M., Bucks, R. S., Rodrigues, M., Beilby, J., Howard, M., Taddei, K., Martins, G., Paton, A., Shah, T., Dhaliwal, S. S., Foster, J. K., Martins, I. J., Lautenschlager, N. T., Mastaglia, F. L., Gandy, S. E., & Martins, R. N. (2017). Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. International Journal of Neuroscience, 127(3), 243-252. https://doi.org/10.1080/00207454.2016.1182527

@article{7f5659336df445719a696b5d232189fb,

title = "Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women",

abstract = "Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p ",

keywords = "ageing, apolipoprotein E, cognitive function, high-density lipoprotein, memory, women",

author = "Bates, {Kristyn A.} and Sohrabi, {Hamid R.} and Rainey-Smith, {Stephanie R.} and Michael Weinborn and Bucks, {Romola S.} and Mark Rodrigues and John Beilby and Matthew Howard and Kevin Taddei and Georgia Martins and Athena Paton and Tejal Shah and Dhaliwal, {Satvinder S.} and Foster, {Jonathan K.} and Martins, {Ian J.} and Lautenschlager, {Nicola T.} and Mastaglia, {Frank L.} and Gandy, {Samuel E.} and Martins, {Ralph N.}",

year = "2017",

month = mar,

day = "4",

doi = "10.1080/00207454.2016.1182527",

language = "English",

volume = "127",

pages = "243--252",

journal = "International Journal of Neuroscience",

issn = "0020-7454",

publisher = "Informa Healthcare USA",

number = "3",

}

Bates, KA, Sohrabi, HR, Rainey-Smith, SR , Weinborn, M , Bucks, RS, Rodrigues, M, Beilby, J, Howard, M, Taddei, K, Martins, G, Paton, A, Shah, T, Dhaliwal, SS, Foster, JK, Martins, IJ, Lautenschlager, NT, Mastaglia, FL, Gandy, SE & Martins, RN 2017, 'Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women', International Journal of Neuroscience, vol. 127, no. 3, pp. 243-252. https://doi.org/10.1080/00207454.2016.1182527

TY - JOUR

T1 - Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women

AU - Bates, Kristyn A.

AU - Sohrabi, Hamid R.

AU - Rainey-Smith, Stephanie R.

AU - Weinborn, Michael

AU - Bucks, Romola S.

AU - Rodrigues, Mark

AU - Beilby, John

AU - Howard, Matthew

AU - Taddei, Kevin

AU - Martins, Georgia

AU - Paton, Athena

AU - Shah, Tejal

AU - Dhaliwal, Satvinder S.

AU - Foster, Jonathan K.

AU - Martins, Ian J.

AU - Lautenschlager, Nicola T.

AU - Mastaglia, Frank L.

AU - Gandy, Samuel E.

AU - Martins, Ralph N.

PY - 2017/3/4

Y1 - 2017/3/4

N2 - Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p

AB - Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n = 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F = 3.062; p

KW - ageing

KW - apolipoprotein E

KW - cognitive function

KW - high-density lipoprotein

KW - memory

KW - women

UR - http://www.scopus.com/inward/record.url?scp=84966769758&partnerID=8YFLogxK

U2 - 10.1080/00207454.2016.1182527

DO - 10.1080/00207454.2016.1182527

M3 - Article

C2 - 27113638

AN - SCOPUS:84966769758

SN - 0020-7454

VL - 127

SP - 243

EP - 252

JO - International Journal of Neuroscience

JF - International Journal of Neuroscience

IS - 3

ER -

Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this