Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Rui Li; Xiaobo Sun; Yaqing Shu; Yuge Wang; Li Xiao; Zhanhang Wang; Xueqiang Hu; Allan G. Kermode; Wei Qiu

doi:10.1016/j.jneuroim.2017.10.013

Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Rui Li, Xiaobo Sun, Yaqing Shu, Yuge Wang, Li Xiao, Zhanhang Wang, Xueqiang Hu, Allan G. Kermode, Wei Qiu

Centre for Neuromuscular and Neurological Disorders (Perron Institute)

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

Original language	English
Pages (from-to)	56-60
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	313
DOIs	https://doi.org/10.1016/j.jneuroim.2017.10.013
Publication status	Published - 15 Dec 2017

Access to Document

10.1016/j.jneuroim.2017.10.013

Cite this

@article{0796ed13014b4baaad899a09c09de15c,

title = "Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients",

abstract = "CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.",

keywords = "CCL20, Multiple sclerosis, SIRT1",

author = "Rui Li and Xiaobo Sun and Yaqing Shu and Yuge Wang and Li Xiao and Zhanhang Wang and Xueqiang Hu and Kermode, {Allan G.} and Wei Qiu",

year = "2017",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2017.10.013",

language = "English",

volume = "313",

pages = "56--60",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

}

TY - JOUR

T1 - Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

AU - Li, Rui

AU - Sun, Xiaobo

AU - Shu, Yaqing

AU - Wang, Yuge

AU - Xiao, Li

AU - Wang, Zhanhang

AU - Hu, Xueqiang

AU - Kermode, Allan G.

AU - Qiu, Wei

PY - 2017/12/15

Y1 - 2017/12/15

N2 - CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

AB - CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

KW - CCL20

KW - Multiple sclerosis

KW - SIRT1

UR - http://www.scopus.com/inward/record.url?scp=85032264385&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2017.10.013

DO - 10.1016/j.jneuroim.2017.10.013

M3 - Article

C2 - 29153609

AN - SCOPUS:85032264385

SN - 0165-5728

VL - 313

SP - 56

EP - 60

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Abstract

Access to Document

Other files and links

Fingerprint

Cite this