Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients

Rui Li, Xiaobo Sun, Yaqing Shu, Yuge Wang, Li Xiao, Zhanhang Wang, Xueqiang Hu, Allan G. Kermode, Wei Qiu

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

CCL20 is a potentially important component in the pathogenesis of multiple sclerosis (MS). SIRT1 exhibits a negative regulatory effect on a variety of inflammatory cytokines and can relieve experimental autoimmune encephalomyelitis. The association between the level of CCL20 and SIRT1 activity in MS patients has not been investigated. In the present study, blood samples were collected from 38 RRMS patients and 40 healthy controls. The serum CCL20 levels were measured by ELISA. SIRT1 activity was evaluated by fluorometric assay. We revealed elevated serum CCL20 concentrations in MS, and discovered an inverse correlation between CCL20 and SIRT1 activity in MS patients.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalJournal of Neuroimmunology
Volume313
DOIs
Publication statusPublished - 15 Dec 2017

Fingerprint

Dive into the research topics of 'Serum CCL20 and its association with SIRT1 activity in multiple sclerosis patients'. Together they form a unique fingerprint.

Cite this