Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Lucinda Black, Sally Burrows, R.M. Lucas, Carina Marshall, Rae-Chi Huang, Wendy Chan She Ping-Delfos, Lawrence Beilin, Patrick Holt, Prudence Hart, Wendy Oddy, Trevor Mori

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Abstract

© The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 % CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 % CI -0·003, -0·001; P
Original languageEnglish
Pages (from-to)1994-2002
JournalBritish Journal of Nutrition
Volume115
Issue number11
Early online date8 Apr 2016
DOIs
Publication statusPublished - Jun 2016

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Young Adult
Serum
Insulin Resistance
Homeostasis
Blood Pressure
25-hydroxyvitamin D
HDL Cholesterol
Linear Models
Cohort Studies
Pregnancy
Population

Cite this

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title = "Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults",
abstract = "{\circledC} The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 {\%} CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 {\%} CI -0·003, -0·001; P",
author = "Lucinda Black and Sally Burrows and R.M. Lucas and Carina Marshall and Rae-Chi Huang and {Chan She Ping-Delfos}, Wendy and Lawrence Beilin and Patrick Holt and Prudence Hart and Wendy Oddy and Trevor Mori",
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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults. / Black, Lucinda; Burrows, Sally; Lucas, R.M.; Marshall, Carina; Huang, Rae-Chi; Chan She Ping-Delfos, Wendy; Beilin, Lawrence; Holt, Patrick; Hart, Prudence; Oddy, Wendy; Mori, Trevor.

In: British Journal of Nutrition, Vol. 115, No. 11, 06.2016, p. 1994-2002.

Research output: Contribution to journalArticle

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AU - Black, Lucinda

AU - Burrows, Sally

AU - Lucas, R.M.

AU - Marshall, Carina

AU - Huang, Rae-Chi

AU - Chan She Ping-Delfos, Wendy

AU - Beilin, Lawrence

AU - Holt, Patrick

AU - Hart, Prudence

AU - Oddy, Wendy

AU - Mori, Trevor

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AB - © The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 % CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 % CI -0·003, -0·001; P

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M3 - Article

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JF - The British Journal of Nutrition

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