Projects per year
Abstract
© The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 % CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 % CI -0·003, -0·001; P
Original language | English |
---|---|
Pages (from-to) | 1994-2002 |
Number of pages | 9 |
Journal | British Journal of Nutrition |
Volume | 115 |
Issue number | 11 |
Early online date | 8 Apr 2016 |
DOIs | |
Publication status | Published - 14 Jun 2016 |
Fingerprint
Dive into the research topics of 'Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Nutritional determinants of Cardiometabolic risk & mental health disorders from infancy to adulthood
Oddy, W., Mori, T., Adams, L. & Byrne, S.
National Health & Medical Research Council NHMRC
1/01/12 → 31/12/14
Project: Research
-
403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
Beilin, L., Palmer, L., Oddy, W., Mori, T., Kendall, G. & Hands, B.
1/01/06 → 31/12/09
Project: Research
-
Determinants of Child Health and Development: Populations, Partnerships, Pathways and Prevention.
Stanley, F., De Klerk, N., Lehmann, D., Leonard, H., Zubrick, S., Silburn, S. & Bower, C.
1/01/05 → 31/12/09
Project: Research