Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1994-2002 |
| Journal | British Journal of Nutrition |
| Volume | 115 |
| Issue number | 11 |
| Early online date | 8 Apr 2016 |
| DOIs | |
| Publication status | Published - Jun 2016 |
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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults. / Black, Lucinda; Burrows, Sally; Lucas, R.M.; Marshall, Carina; Huang, Rae-Chi; Chan She Ping-Delfos, Wendy; Beilin, Lawrence; Holt, Patrick; Hart, Prudence; Oddy, Wendy; Mori, Trevor.
In: British Journal of Nutrition, Vol. 115, No. 11, 06.2016, p. 1994-2002.Research output: Contribution to journal › Article
TY - JOUR
T1 - Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults
AU - Black, Lucinda
AU - Burrows, Sally
AU - Lucas, R.M.
AU - Marshall, Carina
AU - Huang, Rae-Chi
AU - Chan She Ping-Delfos, Wendy
AU - Beilin, Lawrence
AU - Holt, Patrick
AU - Hart, Prudence
AU - Oddy, Wendy
AU - Mori, Trevor
PY - 2016/6
Y1 - 2016/6
N2 - © The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 % CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 % CI -0·003, -0·001; P
AB - © The Authors 2016. Evidence associating serum 25-hydroxyvitamin D (25(OH)D) concentrations and cardiometabolic risk factors is inconsistent and studies have largely been conducted in adult populations. We examined the prospective associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the West Australian Pregnancy Cohort (Raine) Study. Serum 25(OH)D concentrations, BMI, homoeostasis model assessment for insulin resistance (HOMA-IR), TAG, HDL-cholesterol and systolic blood pressure (SBP) were measured at the 17-year (n 1015) and 20-year (n 1117) follow-ups. Hierarchical linear mixed models with maximum likelihood estimation were used to investigate associations between serum 25(OH)D concentrations and cardiometabolic risk factors, accounting for potential confounders. In males and females, respectively, mean serum 25(OH)D concentrations were 73·6 (sd 28·2) and 75·4 (sd 25·9) nmol/l at 17 years and 70·0 (sd 24·2) and 74·3 (sd 26·2) nmol/l at 20 years. Deseasonalised serum 25(OH)D3 concentrations were inversely associated with BMI (coefficient -0·01; 95 % CI -0·03, -0·003; P=0·014). No change over time was detected in the association for males; for females, the inverse association was stronger at 20 years compared with 17 years. Serum 25(OH)D concentrations were inversely associated with log-HOMA-IR (coefficient -0·002; 95 % CI -0·003, -0·001; P
U2 - 10.1017/S0007114516001185
DO - 10.1017/S0007114516001185
M3 - Article
VL - 115
SP - 1994
EP - 2002
JO - The British Journal of Nutrition
JF - The British Journal of Nutrition
SN - 0007-1145
IS - 11
ER -