Serological responses to target Streptococcus pyogenes vaccine antigens in patients with proven invasive beta-haemolytic streptococcal infections

Kristyn Langworthy

Research output: ThesisMaster's Thesis

23 Downloads (Pure)

Abstract

Invasive beta haemotytic streptococcal infections (iBHS) are increasing in Western Australia and globally. There are associated with a high economic and health burden due to mortality and morbidity related to infection. This study was unique in looking at responses to six antigens which are currently being studied for vaccine development in Group A streptococcal infections but across multiple serotypes in adult patients with a proven iBHS. There was evidence in this study that there is a robust antigen response across subtypes with the potential to target a universal antigen for a broad vaccine that would protect across multiple Streptococcal strains.
Original languageEnglish
QualificationMasters
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Manning, Laurens, Supervisor
  • Raby, Edward, Supervisor
Thesis sponsors
Award date28 Feb 2024
DOIs
Publication statusUnpublished - 2023

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