Projects per year
Abstract
© 2016 The Royal Society of Chemistry.Basal-like breast cancers are highly aggressive malignancies associated with very poor prognosis. Although these cancers may initially respond to first-line treatment, they become highly resistant to standard chemotherapy in the metastatic setting. Chemotherapy resistance in basal-like breast cancers is associated with highly selective overexpression of the homeobox transcription factor Engrailed 1 (EN1). Herein, we propose a novel therapeutic strategy using poly(glycidyl methacrylate) nanoparticles decorated with poly(acrylic acid) that enable dual delivery of docetaxel and interference peptides designed to block or inhibit EN1 (EN1-iPep). We demonstrate that EN1-iPep is highly selective in inducing apoptotic cell death in basal-like cancer cells with negligible effects in a non-neoplastic human mammary epithelial cell line. Furthermore, we show that treatment with EN1-iPep results in a highly synergistic pharmacological interaction with docetaxel in inhibiting cancer cell growth. The incorporation of these two agents in a single nanoformulation results in greater anticancer efficacy than current nanoparticle-based treatments used in the clinical setting.
Original language | English |
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Pages (from-to) | 9343-9353 |
Journal | Nanoscale |
Volume | 8 |
Issue number | 17 |
DOIs | |
Publication status | Published - 11 Apr 2016 |
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Dive into the research topics of 'Sensitizing basal-like breast cancer to chemotherapy using nanoparticles conjugated with interference peptide'. Together they form a unique fingerprint.Projects
- 4 Finished
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Magnetofection In An Oscillating Magnetic Field
Swaminatha Iyer, K., Blancafort, P., St Pierre, T., Saunders, M., Stubbs, K. & Dobson, J.
1/01/15 → 31/12/17
Project: Research
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Epigenetic reprogramming of malignant breast cancer
Blancafort, P., Lister, R. & Swaminatha Iyer, K.
National Health & Medical Research Council NHMRC
1/01/14 → 31/12/18
Project: Research