@article{cb659f8602de483fa70727240e0f182b,
title = "Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams",
abstract = "AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams. ",
keywords = "Acetylglucosaminidase/antagonists & inhibitors, Anti-Bacterial Agents/chemistry, Azepines/chemistry, Bacterial Proteins/antagonists & inhibitors, Binding Sites, Catalytic Domain, Crystallography, X-Ray, Drug Resistance, Bacterial/drug effects, Enzyme Inhibitors/chemistry, Hydrogen Bonding, Pseudomonas aeruginosa/drug effects, beta-Lactamases/metabolism, beta-Lactams/chemistry",
author = "Martine Mondon and Soo Hur and Grishma Vadlamani and Prerana Rodrigues and Polina Tsybina and Antonio Oliver and Mark, {Brian L} and Vocadlo, {David J} and Yves Bl{\'e}riot",
year = "2013",
month = dec,
day = "4",
doi = "10.1039/c3cc46646a",
language = "English",
volume = "49",
pages = "10983--5",
journal = "Chemical Communications, 2000",
issn = "1359-7345",
publisher = "ROYAL SOC CHEMISTRY",
number = "93",
}