Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

Martine Mondon, Soo Hur, Grishma Vadlamani, Prerana Rodrigues, Polina Tsybina, Antonio Oliver, Brian L Mark, David J Vocadlo, Yves Blériot

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

AmpC β-lactamase confers resistance to β-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to β-lactams.

Original languageEnglish
Pages (from-to)10983-5
Number of pages3
JournalChemical Communications, 2000
Volume49
Issue number93
DOIs
Publication statusPublished - 4 Dec 2013
Externally publishedYes

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