Selective dopamine D1 and D2 agonists independently affect different components of the free-running circadian rhythm of locomotor activity in rats

Naoto Yamada; Mathew T. Martin-Iverson

doi:10.1016/0006-8993(91)90445-2

Selective dopamine D₁ and D₂ agonists independently affect different components of the free-running circadian rhythm of locomotor activity in rats

Naoto Yamada, Mathew T. Martin-Iverson

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

The effects of selective dopamine D₁ (SKF 38393) and D₂ (4-propyl-9-hydroxynaphthoxazine or PHNO) agonists on free-running rhythms of locomotor activity in rats were investigated under either constant light (LL) or dark (DD) condition. Rats under the DD condition exhibited clear circadian patterns of activity, while circadian patterns of activity in animals kept under the LL condition were more ambiguous. Under the DD condition, SKF 38393 significantly increased the length of the period of free-running rhythms of locomotor activity but had no effect on the amplitude and the mesor, while PHNO significantly increased the amplitude and the mesor of free-running rhythms but had no effect on the length of the period.

Original language	English
Pages (from-to)	310-312
Number of pages	3
Journal	Brain Research
Volume	538
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90445-2
Publication status	Published - 11 Jan 1991
Externally published	Yes

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10.1016/0006-8993(91)90445-2

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title = "Selective dopamine D1 and D2 agonists independently affect different components of the free-running circadian rhythm of locomotor activity in rats",

abstract = "The effects of selective dopamine D1 (SKF 38393) and D2 (4-propyl-9-hydroxynaphthoxazine or PHNO) agonists on free-running rhythms of locomotor activity in rats were investigated under either constant light (LL) or dark (DD) condition. Rats under the DD condition exhibited clear circadian patterns of activity, while circadian patterns of activity in animals kept under the LL condition were more ambiguous. Under the DD condition, SKF 38393 significantly increased the length of the period of free-running rhythms of locomotor activity but had no effect on the amplitude and the mesor, while PHNO significantly increased the amplitude and the mesor of free-running rhythms but had no effect on the length of the period.",

keywords = "4-Propyl-9-hydroxynaphthoxazine, Circadian rhythm, Constant light and dark, D receptor, Dopamine, Free-running rhythm, Rat, SKF 38393",

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AU - Martin-Iverson, Mathew T.

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