SEIZURES DUE TO MULTIPLE-SCLEROSIS - 7-PATIENTS WITH MRI CORRELATIONS

AJ THOMPSON, AG KERMODE, IF MOSELEY, DG MACMANUS, WI MCDONALD

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Abstract

The MRI data of seven patients with clinically definite multiple sclerosis who developed epileptic seizures are presented. Six of these cases demonstrated new or enhancing lesions. Cerebral biopsy in one of these lesions. confirmed inflammation with myelin breakdown products. Lesions implicated in the causation of seizures involved the cortex or subcortical area. In one patient, a new lesion was associated with EEG abnormalities which resolved as the lesion reduced in size. In three patients epileptic activity was the only clinical manifestation of disease. Large, unresolving lesions tended to be associated with continuing seizures.

Original languageEnglish
Pages (from-to)1317-1320
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume56
Issue number12
DOIs
Publication statusPublished - Dec 1993

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