Segregation analysis of asthma and respiratory allergy in population-based samples of families

S. Turner; P. Rye; Neil Gibson; P.K. Judge; Lyle Palmer; D. Turner; S. Stick; Louis Landau; Peter Le Souef

Segregation analysis of asthma and respiratory allergy in population-based samples of families

S. Turner, P. Rye, Neil Gibson, P.K. Judge, Lyle Palmer, D. Turner, S. Stick, Louis Landau, Peter Le Souef

Research output: Chapter in Book/Conference paper › Conference paper

1 Citation (Web of Science)

Abstract

Class A regressive multiple logistic segregation models with a sibling covariate were used to investigate the underlying determinants of asthma and respiratory allergy (defined from specific IgE levels to inhaled allergens) in the randomly recruited Caucasian families from the Genetic Analysis Workshop 12 asthma data sets - Perth, Busselton, and Southampton. For asthma, both a purely multifactorial model and a major gene (dominant or recessive) model with multifactorial effects fitted the data. For respiratory allergy, a dominant, dominant with multifactorial effects and a purely multifactorial model all fitted the data. However, homogeneity of the three studies was rejected for both traits indicating that the three populations are significantly different and should be analyzed separately. This finding has implications for the meta-analysis of asthma linkage studies. (C) 2001 Wiley-Liss, Inc.

Original language	English
Title of host publication	Thoracic Society of Australia and New Zealand
Editors	P.J. Thompson
Place of Publication	Carlton South, Victoria
Publisher	Blackwell
Pages	A47
Volume	Supplement 6
Edition	Brisbane Australia
ISBN (Print)	13237799
Publication status	Published - 2001
Event	Segregation analysis of asthma and respiratory allergy in population-based samples of families - Brisbane Australia Duration: 1 Jan 2001 → …

Conference

Conference	Segregation analysis of asthma and respiratory allergy in population-based samples of families
Period	1/01/01 → …

Cite this

@inproceedings{a52a6af5458f4d58b252c599599ed8f7,

title = "Segregation analysis of asthma and respiratory allergy in population-based samples of families",

abstract = "Class A regressive multiple logistic segregation models with a sibling covariate were used to investigate the underlying determinants of asthma and respiratory allergy (defined from specific IgE levels to inhaled allergens) in the randomly recruited Caucasian families from the Genetic Analysis Workshop 12 asthma data sets - Perth, Busselton, and Southampton. For asthma, both a purely multifactorial model and a major gene (dominant or recessive) model with multifactorial effects fitted the data. For respiratory allergy, a dominant, dominant with multifactorial effects and a purely multifactorial model all fitted the data. However, homogeneity of the three studies was rejected for both traits indicating that the three populations are significantly different and should be analyzed separately. This finding has implications for the meta-analysis of asthma linkage studies. (C) 2001 Wiley-Liss, Inc.",

author = "S. Turner and P. Rye and Neil Gibson and P.K. Judge and Lyle Palmer and D. Turner and S. Stick and Louis Landau and {Le Souef}, Peter",

year = "2001",

language = "English",

isbn = "13237799",

volume = "Supplement 6",

pages = "A47",

editor = "P.J. Thompson",

booktitle = "Thoracic Society of Australia and New Zealand",

publisher = "Blackwell",

address = "United Kingdom",

edition = "Brisbane Australia",

note = "Segregation analysis of asthma and respiratory allergy in population-based samples of families ; Conference date: 01-01-2001",

}

Turner, S, Rye, P, Gibson, N, Judge, PK, Palmer, L, Turner, D, Stick, S, Landau, L & Le Souef, P 2001, Segregation analysis of asthma and respiratory allergy in population-based samples of families. in PJ Thompson (ed.), Thoracic Society of Australia and New Zealand. Brisbane Australia edn, vol. Supplement 6, Blackwell, Carlton South, Victoria, pp. A47, Segregation analysis of asthma and respiratory allergy in population-based samples of families, 1/01/01.

TY - GEN

T1 - Segregation analysis of asthma and respiratory allergy in population-based samples of families

AU - Turner, S.

AU - Rye, P.

AU - Gibson, Neil

AU - Judge, P.K.

AU - Palmer, Lyle

AU - Turner, D.

AU - Stick, S.

AU - Landau, Louis

AU - Le Souef, Peter

PY - 2001

Y1 - 2001

N2 - Class A regressive multiple logistic segregation models with a sibling covariate were used to investigate the underlying determinants of asthma and respiratory allergy (defined from specific IgE levels to inhaled allergens) in the randomly recruited Caucasian families from the Genetic Analysis Workshop 12 asthma data sets - Perth, Busselton, and Southampton. For asthma, both a purely multifactorial model and a major gene (dominant or recessive) model with multifactorial effects fitted the data. For respiratory allergy, a dominant, dominant with multifactorial effects and a purely multifactorial model all fitted the data. However, homogeneity of the three studies was rejected for both traits indicating that the three populations are significantly different and should be analyzed separately. This finding has implications for the meta-analysis of asthma linkage studies. (C) 2001 Wiley-Liss, Inc.

AB - Class A regressive multiple logistic segregation models with a sibling covariate were used to investigate the underlying determinants of asthma and respiratory allergy (defined from specific IgE levels to inhaled allergens) in the randomly recruited Caucasian families from the Genetic Analysis Workshop 12 asthma data sets - Perth, Busselton, and Southampton. For asthma, both a purely multifactorial model and a major gene (dominant or recessive) model with multifactorial effects fitted the data. For respiratory allergy, a dominant, dominant with multifactorial effects and a purely multifactorial model all fitted the data. However, homogeneity of the three studies was rejected for both traits indicating that the three populations are significantly different and should be analyzed separately. This finding has implications for the meta-analysis of asthma linkage studies. (C) 2001 Wiley-Liss, Inc.

M3 - Conference paper

SN - 13237799

VL - Supplement 6

SP - A47

BT - Thoracic Society of Australia and New Zealand

A2 - Thompson, P.J.

PB - Blackwell

CY - Carlton South, Victoria

T2 - Segregation analysis of asthma and respiratory allergy in population-based samples of families

Y2 - 1 January 2001

ER -

Segregation analysis of asthma and respiratory allergy in population-based samples of families

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