Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

Michael J. Wheeler; Paddy C. Dempsey; Megan S. Grace; Kathryn A. Ellis; Paul A. Gardiner; Daniel J. Green; David W. Dunstan

doi:10.1016/j.trci.2017.04.001

Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

Michael J. Wheeler, Paddy C. Dempsey, Megan S. Grace, Kathryn A. Ellis, Paul A. Gardiner, Daniel J. Green, David W. Dunstan

School of Human Sciences

Research output: Contribution to journal › Short survey › peer-review

118 Citations (Scopus)

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Abstract

Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.

Original language	English
Pages (from-to)	291-300
Number of pages	10
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	3
DOIs	https://doi.org/10.1016/j.trci.2017.04.001
Publication status	Published - 1 Sept 2017

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Sedentary behavior as a risk factor for cognitive decline. A focus on the influence of glycemic control in brain healthFinal published version, 1.16 MBLicence: CC BY-NC-ND

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Wheeler, M. J., Dempsey, P. C., Grace, M. S., Ellis, K. A., Gardiner, P. A., Green, D. J., & Dunstan, D. W. (2017). Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(3), 291-300. https://doi.org/10.1016/j.trci.2017.04.001

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abstract = "Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.",

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Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. / Wheeler, Michael J.; Dempsey, Paddy C.; Grace, Megan S. et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 3, 01.09.2017, p. 291-300.

Research output: Contribution to journal › Short survey › peer-review

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AU - Wheeler, Michael J.

AU - Dempsey, Paddy C.

AU - Grace, Megan S.

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AU - Gardiner, Paul A.

AU - Green, Daniel J.

AU - Dunstan, David W.

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N2 - Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.

AB - Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.

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KW - Breaks in sedentary time

KW - Cognitive function

KW - Dementia

KW - Diabetes

KW - Exercise

KW - Glucose metabolism

KW - Light-intensity activity

KW - Physical activity

KW - Sedentary behavior

KW - Sitting

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Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

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