Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

Michael J. Wheeler, Paddy C. Dempsey, Megan S. Grace, Kathryn A. Ellis, Paul A. Gardiner, Daniel J. Green, David W. Dunstan

Research output: Contribution to journalShort survey

31 Citations (Scopus)
352 Downloads (Pure)

Abstract

Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume3
Issue number3
DOIs
Publication statusPublished - 1 Sep 2017

Fingerprint Dive into the research topics of 'Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health'. Together they form a unique fingerprint.

  • Cite this