Secreted frizzled related proteins: Implications in cancers

R. Surana, S. Sikka, W. Cai, E. Shin, S.R. Warrier, H.J.G. Tan, Frank Arfuso, S.A. Fox, Arunasalam Dharmarajan, Alan Kumar

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)53-65
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1845
Issue number1
DOIs
Publication statusPublished - 2013

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Neoplasms
Epigenomics
Frizzled Receptors
FRZB protein
Methylation
Embryonic Development
Cell Movement
Cell Differentiation
Carcinogenesis
Homeostasis
Cell Proliferation
Ligands
Gene Expression

Cite this

Surana, R., Sikka, S., Cai, W., Shin, E., Warrier, S. R., Tan, H. J. G., ... Kumar, A. (2013). Secreted frizzled related proteins: Implications in cancers. Biochimica et Biophysica Acta - Reviews on Cancer, 1845(1), 53-65. https://doi.org/10.1016/j.bbcan.2013.11.004
Surana, R. ; Sikka, S. ; Cai, W. ; Shin, E. ; Warrier, S.R. ; Tan, H.J.G. ; Arfuso, Frank ; Fox, S.A. ; Dharmarajan, Arunasalam ; Kumar, Alan. / Secreted frizzled related proteins: Implications in cancers. In: Biochimica et Biophysica Acta - Reviews on Cancer. 2013 ; Vol. 1845, No. 1. pp. 53-65.
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Secreted frizzled related proteins: Implications in cancers. / Surana, R.; Sikka, S.; Cai, W.; Shin, E.; Warrier, S.R.; Tan, H.J.G.; Arfuso, Frank; Fox, S.A.; Dharmarajan, Arunasalam; Kumar, Alan.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1845, No. 1, 2013, p. 53-65.

Research output: Contribution to journalReview article

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AU - Surana, R.

AU - Sikka, S.

AU - Cai, W.

AU - Shin, E.

AU - Warrier, S.R.

AU - Tan, H.J.G.

AU - Arfuso, Frank

AU - Fox, S.A.

AU - Dharmarajan, Arunasalam

AU - Kumar, Alan

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N2 - The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers. © 2013 Elsevier B.V.

AB - The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers. © 2013 Elsevier B.V.

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