Second trimester amniotic fluid cytokine concentrations, Ureaplasma sp. colonisation status and sexual activity as predictors of preterm birth in Chinese and Australian women

Matt Payne, Z Feng, Shaofu Li, Dorota Doherty, B Xu, J Li, L Liu, Jeffrey Keelan, YH Zhou, Jan Dickinson, Y Hu, John Newnham

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Background
    This study tested if second trimester amniotic fluid cytokine levels, Ureaplasma sp. colonisation and sexual activity predict preterm birth and explain the differential preterm birth rates in Chinese compared to Australian women.

    Methods
    Amniotic fluid was collected by amniocentesis (Chinese 480, Australian 492). Cytokines were measured by multiplex assay and Ureaplasma sp. DNA was detected by PCR analysis. Lifestyle factors, including history of smoking and sexual activity during pregnancy, were obtained through completion of questionnaires upon recruitment to the study.

    Results
    Inflammatory cytokine concentrations were poorly predictive of preterm birth. Ureaplasma sp. was detected in two of the Chinese pregnancies and none from Australia. Sexual activity was less frequent in Chinese, and was not associated with preterm birth or amniotic fluid findings in either population.

    Discussion
    Second trimester amniocentesis for measurement of inflammatory markers and Ureaplasma sp. DNA was not indicative of risk of preterm birth, at least in these populations. The lower rate of preterm birth in China was not explained by differences in amniotic fluid inflammatory markers, Ureaplasma sp. colonisation, or sexual activity.
    Original languageEnglish
    Pages (from-to)340-
    JournalBMC Pregnancy and Childbirth
    Volume14
    DOIs
    Publication statusPublished - 30 Sep 2014

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