Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients

Joe Sasadeusz; Andrew Grigg; Peter D. Hughes; Seng Lee Lim; Michaela Lucas; Geoff McColl; Sue Anne McLachlan; Marion G. Peters; Nicholas Shackel; Monica Slavin; Vijaya Sundararajan; Alexander Thompson; Joseph Doyle; James Rickard; Peter De Cruz; Robert G. Gish; Kumar Visvanathan

doi:10.1016/j.cld.2019.04.010

Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients

Joe Sasadeusz, Andrew Grigg, Peter D. Hughes, Seng Lee Lim, Michaela Lucas, Geoff McColl, Sue Anne McLachlan, Marion G. Peters, Nicholas Shackel, Monica Slavin, Vijaya Sundararajan, Alexander Thompson, Joseph Doyle, James Rickard, Peter De Cruz, Robert G. Gish, Kumar Visvanathan

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti–hepatitis B core antibody-positive only or both anti–hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.

Original language	English
Pages (from-to)	493-509
Number of pages	17
Journal	Clinics in Liver Disease
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.cld.2019.04.010
Publication status	Published - 1 Aug 2019

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Sasadeusz, J., Grigg, A., Hughes, P. D., Lee Lim, S., Lucas, M., McColl, G., McLachlan, S. A., Peters, M. G., Shackel, N., Slavin, M., Sundararajan, V., Thompson, A., Doyle, J., Rickard, J., De Cruz, P., Gish, R. G., & Visvanathan, K. (2019). Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients. Clinics in Liver Disease, 23(3), 493-509. https://doi.org/10.1016/j.cld.2019.04.010

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title = "Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients",

abstract = "Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti–hepatitis B core antibody-positive only or both anti–hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.",

keywords = "Hepatitis B, Prophylaxis, Reactivation, Transmission, Transplantation",

author = "Joe Sasadeusz and Andrew Grigg and Hughes, {Peter D.} and {Lee Lim}, Seng and Michaela Lucas and Geoff McColl and McLachlan, {Sue Anne} and Peters, {Marion G.} and Nicholas Shackel and Monica Slavin and Vijaya Sundararajan and Alexander Thompson and Joseph Doyle and James Rickard and {De Cruz}, Peter and Gish, {Robert G.} and Kumar Visvanathan",

year = "2019",

month = aug,

day = "1",

doi = "10.1016/j.cld.2019.04.010",

language = "English",

volume = "23",

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journal = "Clinics in Liver Disease",

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publisher = "W.B. Saunders Ltd",

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Sasadeusz, J, Grigg, A, Hughes, PD, Lee Lim, S, Lucas, M, McColl, G, McLachlan, SA, Peters, MG, Shackel, N, Slavin, M, Sundararajan, V, Thompson, A, Doyle, J, Rickard, J, De Cruz, P, Gish, RG & Visvanathan, K 2019, 'Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients', Clinics in Liver Disease, vol. 23, no. 3, pp. 493-509. https://doi.org/10.1016/j.cld.2019.04.010

TY - JOUR

T1 - Screening and Prophylaxis to Prevent Hepatitis B Reactivation

T2 - Transplant Recipients

AU - Sasadeusz, Joe

AU - Grigg, Andrew

AU - Hughes, Peter D.

AU - Lee Lim, Seng

AU - Lucas, Michaela

AU - McColl, Geoff

AU - McLachlan, Sue Anne

AU - Peters, Marion G.

AU - Shackel, Nicholas

AU - Slavin, Monica

AU - Sundararajan, Vijaya

AU - Thompson, Alexander

AU - Doyle, Joseph

AU - Rickard, James

AU - De Cruz, Peter

AU - Gish, Robert G.

AU - Visvanathan, Kumar

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti–hepatitis B core antibody-positive only or both anti–hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.

AB - Organ transplantation is a lifesaving procedure for many patients. To prevent rejection or graft-versus-host disease, recipients require long-term immunosuppression. In patients who have ever been exposed to hepatitis B, it is possible for reactivation to occur; this includes patients who are anti–hepatitis B core antibody-positive only or both anti–hepatitis B core antibody-positive and hepatitis B surface antibody-positive. The susceptibility to this varies with the nature of the transplant. Hepatitis B can be transmitted from donor to recipient. It is important to assess the hepatitis B status and formulate a strategy to prevent transmission and prevent reactivation.

KW - Hepatitis B

KW - Prophylaxis

KW - Reactivation

KW - Transmission

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=85066792338&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2019.04.010

DO - 10.1016/j.cld.2019.04.010

M3 - Review article

C2 - 31266623

AN - SCOPUS:85066792338

SN - 1089-3261

VL - 23

SP - 493

EP - 509

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 3

ER -

Screening and Prophylaxis to Prevent Hepatitis B Reactivation: Transplant Recipients

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