Screen-detected mucinous breast carcinoma: potential for delayed diagnosis

R. Dhillon, P. Depree, C. Metcalf, Liz Wylie

    Research output: Contribution to journalArticle

    30 Citations (Scopus)

    Abstract

    AIM: To describe the imaging features of 34 screen-detected mucinous carcinomas lesions.MATERIALS AND METHODS: The BreastScreen Western Australia (WA) database between January 1991 and December 2003 was searched. During this period, 214,507 women were screened and 2745 cases of invasive carcinoma and 45 cases of mucinous carcinoma were recorded. Case notes, radiology films and pathology reports of patients with mucinous carcinoma were reviewed. Thirty-four radiotogicatly detected pure mucinous carcinomas are described.RESULTS: Of the pure mucinous carcinomas, the average age at diagnosis was 65 years (range 48-82 years), which was higher than that of other women with breast cancer (average age 60 years) screened at BreastScreen WA. Characteristic mammographic features of mucinous carcinoma are well-circumscribed masses with lobulated margins (26/34). Only 39% (11/28) of tumours were detected at ultrasound, as the smatter Lesions less than 15 mm in diameter were often isoechoic with normal fat. Where histological grade was reported at excision, most (25/26) were tow to medium-grade tumours (Bloom, Richardson and Elston grade I and II). A significant number of lesions (13/34) were evident on the previous screening examination where they were misinterpreted as benign lesions. However, none of these cases had positive axitlary lymph nodes at final diagnosis.CONCLUSION: Although mammographically benign appearances of mucinous carcinoma caused a delay in diagnosis in 38% of the present cases, mucinous breast carcinomas have a favourable prognosis, as they are often tow-grade tumours and rarely metastasize. Delay in diagnosis for these tumours in a screening programme may not lead to a significant adverse outcome for most women. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All. rights reserved.
    Original languageEnglish
    Pages (from-to)423-430
    JournalClinical Radiology
    Volume61
    DOIs
    Publication statusPublished - 2006

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    Mucinous Adenocarcinoma
    Delayed Diagnosis
    Breast Neoplasms
    Western Australia
    Neoplasms
    Radiology
    Lymph Nodes
    Fats
    Databases
    Pathology
    Carcinoma

    Cite this

    Dhillon, R. ; Depree, P. ; Metcalf, C. ; Wylie, Liz. / Screen-detected mucinous breast carcinoma: potential for delayed diagnosis. In: Clinical Radiology. 2006 ; Vol. 61. pp. 423-430.
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    title = "Screen-detected mucinous breast carcinoma: potential for delayed diagnosis",
    abstract = "AIM: To describe the imaging features of 34 screen-detected mucinous carcinomas lesions.MATERIALS AND METHODS: The BreastScreen Western Australia (WA) database between January 1991 and December 2003 was searched. During this period, 214,507 women were screened and 2745 cases of invasive carcinoma and 45 cases of mucinous carcinoma were recorded. Case notes, radiology films and pathology reports of patients with mucinous carcinoma were reviewed. Thirty-four radiotogicatly detected pure mucinous carcinomas are described.RESULTS: Of the pure mucinous carcinomas, the average age at diagnosis was 65 years (range 48-82 years), which was higher than that of other women with breast cancer (average age 60 years) screened at BreastScreen WA. Characteristic mammographic features of mucinous carcinoma are well-circumscribed masses with lobulated margins (26/34). Only 39{\%} (11/28) of tumours were detected at ultrasound, as the smatter Lesions less than 15 mm in diameter were often isoechoic with normal fat. Where histological grade was reported at excision, most (25/26) were tow to medium-grade tumours (Bloom, Richardson and Elston grade I and II). A significant number of lesions (13/34) were evident on the previous screening examination where they were misinterpreted as benign lesions. However, none of these cases had positive axitlary lymph nodes at final diagnosis.CONCLUSION: Although mammographically benign appearances of mucinous carcinoma caused a delay in diagnosis in 38{\%} of the present cases, mucinous breast carcinomas have a favourable prognosis, as they are often tow-grade tumours and rarely metastasize. Delay in diagnosis for these tumours in a screening programme may not lead to a significant adverse outcome for most women. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All. rights reserved.",
    author = "R. Dhillon and P. Depree and C. Metcalf and Liz Wylie",
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    Screen-detected mucinous breast carcinoma: potential for delayed diagnosis. / Dhillon, R.; Depree, P.; Metcalf, C.; Wylie, Liz.

    In: Clinical Radiology, Vol. 61, 2006, p. 423-430.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Screen-detected mucinous breast carcinoma: potential for delayed diagnosis

    AU - Dhillon, R.

    AU - Depree, P.

    AU - Metcalf, C.

    AU - Wylie, Liz

    PY - 2006

    Y1 - 2006

    N2 - AIM: To describe the imaging features of 34 screen-detected mucinous carcinomas lesions.MATERIALS AND METHODS: The BreastScreen Western Australia (WA) database between January 1991 and December 2003 was searched. During this period, 214,507 women were screened and 2745 cases of invasive carcinoma and 45 cases of mucinous carcinoma were recorded. Case notes, radiology films and pathology reports of patients with mucinous carcinoma were reviewed. Thirty-four radiotogicatly detected pure mucinous carcinomas are described.RESULTS: Of the pure mucinous carcinomas, the average age at diagnosis was 65 years (range 48-82 years), which was higher than that of other women with breast cancer (average age 60 years) screened at BreastScreen WA. Characteristic mammographic features of mucinous carcinoma are well-circumscribed masses with lobulated margins (26/34). Only 39% (11/28) of tumours were detected at ultrasound, as the smatter Lesions less than 15 mm in diameter were often isoechoic with normal fat. Where histological grade was reported at excision, most (25/26) were tow to medium-grade tumours (Bloom, Richardson and Elston grade I and II). A significant number of lesions (13/34) were evident on the previous screening examination where they were misinterpreted as benign lesions. However, none of these cases had positive axitlary lymph nodes at final diagnosis.CONCLUSION: Although mammographically benign appearances of mucinous carcinoma caused a delay in diagnosis in 38% of the present cases, mucinous breast carcinomas have a favourable prognosis, as they are often tow-grade tumours and rarely metastasize. Delay in diagnosis for these tumours in a screening programme may not lead to a significant adverse outcome for most women. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All. rights reserved.

    AB - AIM: To describe the imaging features of 34 screen-detected mucinous carcinomas lesions.MATERIALS AND METHODS: The BreastScreen Western Australia (WA) database between January 1991 and December 2003 was searched. During this period, 214,507 women were screened and 2745 cases of invasive carcinoma and 45 cases of mucinous carcinoma were recorded. Case notes, radiology films and pathology reports of patients with mucinous carcinoma were reviewed. Thirty-four radiotogicatly detected pure mucinous carcinomas are described.RESULTS: Of the pure mucinous carcinomas, the average age at diagnosis was 65 years (range 48-82 years), which was higher than that of other women with breast cancer (average age 60 years) screened at BreastScreen WA. Characteristic mammographic features of mucinous carcinoma are well-circumscribed masses with lobulated margins (26/34). Only 39% (11/28) of tumours were detected at ultrasound, as the smatter Lesions less than 15 mm in diameter were often isoechoic with normal fat. Where histological grade was reported at excision, most (25/26) were tow to medium-grade tumours (Bloom, Richardson and Elston grade I and II). A significant number of lesions (13/34) were evident on the previous screening examination where they were misinterpreted as benign lesions. However, none of these cases had positive axitlary lymph nodes at final diagnosis.CONCLUSION: Although mammographically benign appearances of mucinous carcinoma caused a delay in diagnosis in 38% of the present cases, mucinous breast carcinomas have a favourable prognosis, as they are often tow-grade tumours and rarely metastasize. Delay in diagnosis for these tumours in a screening programme may not lead to a significant adverse outcome for most women. (c) 2005 The Royal College of Radiologists. Published by Elsevier Ltd. All. rights reserved.

    U2 - 10.1016/j.crad.2005.10.008

    DO - 10.1016/j.crad.2005.10.008

    M3 - Article

    VL - 61

    SP - 423

    EP - 430

    JO - Clinical Radiology

    JF - Clinical Radiology

    SN - 0009-9260

    ER -