SARS-CoV-2 Infection and Childhood Islet Autoimmunity

ENDIA Study Group; Elizabeth A. Davis; Aveni Haynes; Grant Morahan

doi:10.1001/jamapediatrics.2024.6848

SARS-CoV-2 Infection and Childhood Islet Autoimmunity

ENDIA Study Group, Elizabeth A. Davis, Aveni Haynes, Grant Morahan

Research output: Contribution to journal › Article › peer-review

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Abstract

Increased incidence of type 1 diabetes (T1D) has been observed during the COVID-19 pandemic.1 In children who were genetically at risk, SARS-CoV-2 infection was associated with increased risk of islet autoimmunity (IA) in some longitudinal cohorts2 but not others.3 Additionally, COVID-19 may accelerate progression to clinical T1D in children with IA.4 We investigated the potential temporal association between SARS-CoV-2 infection and the development of IA in the longitudinal Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study.

Original language	English
Pages (from-to)	568-570
Number of pages	3
Journal	JAMA Pediatrics
Volume	179
Issue number	5
Early online date	3 Mar 2025
DOIs	https://doi.org/10.1001/jamapediatrics.2024.6848
Publication status	Published - 5 May 2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1001/jamapediatrics.2024.6848Licence: CC BY

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title = "SARS-CoV-2 Infection and Childhood Islet Autoimmunity",

abstract = "Increased incidence of type 1 diabetes (T1D) has been observed during the COVID-19 pandemic.1 In children who were genetically at risk, SARS-CoV-2 infection was associated with increased risk of islet autoimmunity (IA) in some longitudinal cohorts2 but not others.3 Additionally, COVID-19 may accelerate progression to clinical T1D in children with IA.4 We investigated the potential temporal association between SARS-CoV-2 infection and the development of IA in the longitudinal Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study.",

author = "{ENDIA Study Group} and Walker, {Gregory J.} and Kylie-Ann Mallitt and Craig, {Maria E.} and Pat Ashwood and Barry, {Simon C.} and Brown, {James D.} and Joanna Caguicla and Davis, {Elizabeth A.} and Hamilton-Williams, {Emma E.} and Harrison, {Leonard C.} and Aveni Haynes and Tony Huynh and Guinevere Martin and Mcgorm, {Kelly J.} and Grant Morahan and Zin Naing and Helena Oakey and Penno, {Megan A. S.} and Andrea Sevendal and Sinnott, {Richard O.} and Georgia Soldatos and Thomson, {Rebecca L.} and Jason Tye-Din and Vuillermin, {Peter J.} and Ward, {Emily J.} and Wentworth, {John M.} and Colman, {Peter G.} and Couper, {Jennifer J.} and Kim, {Ki Wook} and Rawlinson, {William D.}",

year = "2025",

month = may,

day = "5",

doi = "10.1001/jamapediatrics.2024.6848",

language = "English",

volume = "179",

pages = "568--570",

journal = "JAMA Pediatrics ",

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AU - ENDIA Study Group

AU - Walker, Gregory J.

AU - Mallitt, Kylie-Ann

AU - Craig, Maria E.

AU - Ashwood, Pat

AU - Barry, Simon C.

AU - Brown, James D.

AU - Caguicla, Joanna

AU - Davis, Elizabeth A.

AU - Hamilton-Williams, Emma E.

AU - Harrison, Leonard C.

AU - Haynes, Aveni

AU - Huynh, Tony

AU - Martin, Guinevere

AU - Mcgorm, Kelly J.

AU - Morahan, Grant

AU - Naing, Zin

AU - Oakey, Helena

AU - Penno, Megan A. S.

AU - Sevendal, Andrea

AU - Sinnott, Richard O.

AU - Soldatos, Georgia

AU - Thomson, Rebecca L.

AU - Tye-Din, Jason

AU - Vuillermin, Peter J.

AU - Ward, Emily J.

AU - Wentworth, John M.

AU - Colman, Peter G.

AU - Couper, Jennifer J.

AU - Kim, Ki Wook

AU - Rawlinson, William D.

PY - 2025/5/5

Y1 - 2025/5/5

N2 - Increased incidence of type 1 diabetes (T1D) has been observed during the COVID-19 pandemic.1 In children who were genetically at risk, SARS-CoV-2 infection was associated with increased risk of islet autoimmunity (IA) in some longitudinal cohorts2 but not others.3 Additionally, COVID-19 may accelerate progression to clinical T1D in children with IA.4 We investigated the potential temporal association between SARS-CoV-2 infection and the development of IA in the longitudinal Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study.

AB - Increased incidence of type 1 diabetes (T1D) has been observed during the COVID-19 pandemic.1 In children who were genetically at risk, SARS-CoV-2 infection was associated with increased risk of islet autoimmunity (IA) in some longitudinal cohorts2 but not others.3 Additionally, COVID-19 may accelerate progression to clinical T1D in children with IA.4 We investigated the potential temporal association between SARS-CoV-2 infection and the development of IA in the longitudinal Australian Environmental Determinants of Islet Autoimmunity (ENDIA) study.

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SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Abstract

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Project Grants - Early Environmental Determinants of Pancreatic Islet Autoimmunity: A Pregnancy to Early Life Cohort Study in Children at Risk of Type 1 Diabetes

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SARS-CoV-2 Infection and Childhood Islet Autoimmunity

Abstract

UN SDGs

Access to Document

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Projects

Project Grants - Early Environmental Determinants of Pancreatic Islet Autoimmunity: A Pregnancy to Early Life Cohort Study in Children at Risk of Type 1 Diabetes

Cite this