Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-κB and ERK signaling pathways

H. Li, Z. Zhai, G. Liu, T. Tang, Zhen Lin, Ming Zheng, A. Qin, K. Dai

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Sanguinarine is a natural plant extract that has been supplemented in a number of gingival health products to suppress the growth of dental plaque. However, whether sanguinarine has any effect on teeth and alveolar bone health is still unclear. In this study, we demonstrated for the first time that sanguinarine could suppress osteoclastic bone resorption and osteoclast formation in a dose-dependent manner. Sanguinarine diminished the expression of osteoclast marker genes, including TRAP, cathepsin K, calcitonin receptor, DC-STAMP, V-ATPase d2, NFATc1 and c-fos. Further investigation revealed that sanguinarine attenuated RANKL-mediated IκBα phosphorylation and degradation, leading to the impairment of NF-κB signaling pathway during osteoclast differentiation. In addition, sanguinarine also affected the ERK signaling pathway by inhibiting RANKL-induced ERK phosphorylation. Collectively, this study suggested that sanguinarine has protective effects on teeth and alveolar bone health. © 2012 Elsevier Inc.
    Original languageEnglish
    Pages (from-to)951-956
    JournalBiochemical and Biophysical Research Communications
    Volume430
    Issue number3
    DOIs
    Publication statusPublished - 2013

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