Salivary paracetamol : evaluation of a colorimetric method in assessing deliberate self-poisoning

J. Ryan, C. Mandelt, H. Wade, Samuel Vasikaran

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    3 Citations (Scopus)


    Background: In the laboratory evaluation of suspected paracetamol poisoning, a non-invasive sample type that avoids venepuncture would be an attractive alternative to plasma, particularly in the paediatric setting. Salivary paracetamol measurement has not previously been evaluated in the published medical literature in the setting of deliberate self-poisoning (DSP).Methods: In-house validation experiments (recovery, stability and lower limit-of-detection) were performed on pooled saliva samples using a Roche Acetaminophen assay on a Roche/Hitachi 917 analyser. A clinical study of comparison of paired saliva and plasma samples was also conducted involving adult patients presenting with DSP of paracetamol, the results of which were published previously.Results: The validation experiments using pooled saliva samples showed: (i) mean recovery (paracetamol concentration 37.5–525 mg/L) 100.01% (±0.02 SD); (ii) precision of repeated assay over 24-h period CV
    Original languageEnglish
    Pages (from-to)149-151
    JournalAnnals of Clinical Biochemistry
    Issue number2
    Publication statusPublished - 2009


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