Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: A review

J.M. Jacquet, P. Begue, E. Grimprel, P. Reinert, S. Sandbu, S.A. Silfverdal, G. Faldella, T. Nolan, S. Lambert, Peter Richmond, H. Marchall, D. Roberton, L. Schuerman

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and > 95% mounted a response to acellular pertussis antigens. Rectal temperature > 39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling > 50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines. (c) 2005 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)2440-2448
    JournalVaccine
    Volume24
    Issue number13
    DOIs
    Publication statusPublished - 2006

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