RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements

Danuta M. Sampson; Noha Ali; Alex Au Yong; Rumaanah Jeewa; Saumya Rajgopal; Deepaysh D.C.S. Dutt; Sharaf Mohamed; Shehata Mohamed; Alex Hansen; Moreno Menghini; Fred K. Chen

doi:10.1167/tvst.9.3.10

RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements

Danuta M. Sampson, Noha Ali, Alex Au Yong, Rumaanah Jeewa, Saumya Rajgopal, Deepaysh D.C.S. Dutt, Sharaf Mohamed, Shehata Mohamed, Alex Hansen, Moreno Menghini, Fred K. Chen

Centre for Ophthalmology and Visual Science

Research output: Contribution to journal › Article

Abstract

Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods: Optovue OCTA images (3 × 3 mm) from 126 individuals (105 healthy eyes and 72 eyes with retinal disease) were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively. Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.

Original language	English
Article number	10
Journal	Translational Vision Science and Technology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1167/tvst.9.3.10
Publication status	Published - Feb 2020

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Sampson, D. M., Ali, N., Yong, A. A., Jeewa, R., Rajgopal, S., Dutt, D. D. C. S., Mohamed, S., Mohamed, S., Hansen, A., Menghini, M., & Chen, F. K. (2020). RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements. Translational Vision Science and Technology, 9(3), [10]. https://doi.org/10.1167/tvst.9.3.10

Sampson, Danuta M. ; Ali, Noha ; Yong, Alex Au ; Jeewa, Rumaanah ; Rajgopal, Saumya ; Dutt, Deepaysh D.C.S. ; Mohamed, Sharaf ; Mohamed, Shehata ; Hansen, Alex ; Menghini, Moreno ; Chen, Fred K. / RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements. In: Translational Vision Science and Technology. 2020 ; Vol. 9, No. 3.

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title = "RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements",

abstract = "Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods: Optovue OCTA images (3 × 3 mm) from 126 individuals (105 healthy eyes and 72 eyes with retinal disease) were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch{\textquoteright}s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively. Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.",

keywords = "AngioVue, Normative data, OCTA, Optical coherence tomography angiography, Optovue, Retinal capillary density, Split-spectrum amplitude decorrelation angiography",

author = "Sampson, {Danuta M.} and Noha Ali and Yong, {Alex Au} and Rumaanah Jeewa and Saumya Rajgopal and Dutt, {Deepaysh D.C.S.} and Sharaf Mohamed and Shehata Mohamed and Alex Hansen and Moreno Menghini and Chen, {Fred K.}",

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RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements. / Sampson, Danuta M.; Ali, Noha; Yong, Alex Au; Jeewa, Rumaanah; Rajgopal, Saumya; Dutt, Deepaysh D.C.S.; Mohamed, Sharaf; Mohamed, Shehata; Hansen, Alex; Menghini, Moreno; Chen, Fred K.

In: Translational Vision Science and Technology, Vol. 9, No. 3, 10, 02.2020.

Research output: Contribution to journal › Article

TY - JOUR

T1 - RTVue XR angiovue optical coherence tomography angiography software upgrade impacts on retinal thickness and vessel density measurements

AU - Sampson, Danuta M.

AU - Ali, Noha

AU - Yong, Alex Au

AU - Jeewa, Rumaanah

AU - Rajgopal, Saumya

AU - Dutt, Deepaysh D.C.S.

AU - Mohamed, Sharaf

AU - Mohamed, Shehata

AU - Hansen, Alex

AU - Menghini, Moreno

AU - Chen, Fred K.

PY - 2020/2

Y1 - 2020/2

N2 - Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods: Optovue OCTA images (3 × 3 mm) from 126 individuals (105 healthy eyes and 72 eyes with retinal disease) were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively. Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.

AB - Purpose: To determine the impact of an AngioVue software upgrade on total retinal thickness (RT) and inner retinal vessel density (VD) measurements derived from optical coherence tomography angiography (OCTA). Methods: Optovue OCTA images (3 × 3 mm) from 126 individuals (105 healthy eyes and 72 eyes with retinal disease) were acquired before an upgrade of the AngioVue software, which resulted in an inward shift of the outer boundary of the inner retinal vessels and improved Bruch’s membrane segmentation. Total RT and inner retinal VD values were extracted before and after the software upgrade for comparison. Bias and limits of agreement (LA) were calculated. Results: The mean (SD) age of participants was 46 (17) years. Mean (LA) foveal RT increased by 3.0 (–11 to +17) and 3.7 (–11 to +18) μm (P < 0.001) and parafoveal RT increased by 9.7 (–3.8 to +23) and 6.4 (–2.5 to +15) μm (P < 0.001) in healthy and diseased retina, respectively. Mean (LA) foveal inner retinal VD decreased by 6.6 (2.5–11) and 7.7 (0.4–15) percentage units (P < 0.001) and parafoveal inner retinal VD decreased by 4.1 (1.2–7.0) and 4.7 (0.5–8.9) percentage units (P < 0.001) in healthy and diseased retina, respectively. Conclusions: The AngioVue software upgrade resulted in an unexpected increase in total RT and an expected reduction in inner retinal VD measurements in all regions due to altered segmentation. Translational Relevance: RT and VD measures derived from the newer AngioVue software version are not directly comparable to the reported normative data derived from the older software.

KW - AngioVue

KW - Normative data

KW - OCTA

KW - Optical coherence tomography angiography

KW - Optovue

KW - Retinal capillary density

KW - Split-spectrum amplitude decorrelation angiography

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