Roseopurpurins: Chemical Diversity Enhanced by Convergent Biosynthesis and Forward and Reverse Michael Additions

Zhuo Shang, Zeinab Khalil, Li Li, Angela A. Salim, Michelle Quezada, Pabasara Kalansuriya, Robert J. Capon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cultures of the estuarine fungus Penicillium roseopurpureum (CMB-MF038) yielded a diverse array of polyketides, many of which were related via a highly convergent biosynthetic pathway. In addition to revising and assigning structures, and documenting chemical and biological properties, pro-drug cytotoxic properties were attributed to roseopurpurins H (10) and I (11) on the basis of in situ reverse Michael addition to a cytotoxic Michael acceptor (12).

Original languageEnglish
Pages (from-to)4340-4343
Number of pages4
JournalOrganic Letters
Volume18
Issue number17
DOIs
Publication statusPublished - 2 Sep 2016
Externally publishedYes

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