Role of the Sympathetic Nervous System in Stress-Mediated Cardiovascular Disease

Dagmara Hering, K. Lachowska, Markus Schlaich

    Research output: Contribution to journalReview article

    27 Citations (Scopus)

    Abstract

    © 2015, Springer Science+Business Media New York. A high incidence of acute cardiovascular events and sudden cardiac death following unexpected acute emotional stress or a natural catastrophic disaster has been well-documented over the past decades. Chronic psychosocial factors have been shown to be directly linked to the development of hypertension, cardiovascular disease and stroke. Activation of various neurogenic pathways is an important mediator of acute and chronic stress-induced hypertension and heart disease. Heightened sympathetic activation has been shown to be a critical contributor linking psychogenic effects on cardiovascular regulation to serious and often fatal CV outcomes. Accordingly, several therapeutic approaches that attenuate autonomic imbalance via modulation of increased sympathetic outflow by either non-pharmacological or interventional means have been shown to alleviate clinical symptoms. Likewise stress reduction per se achieved with transcendental medicine has been linked to improved patient outcomes. Therapies that oppose adrenergic activity and/or have the potential to attenuate negative emotions are likely to reduce cardiovascular risk and its adverse consequences attributable to chronic mental stress.
    Original languageEnglish
    Article number80
    Pages (from-to)1-9
    Number of pages9
    JournalCurrent Hypertension Reports
    Volume17
    Issue number10
    Early online date29 Aug 2015
    DOIs
    Publication statusPublished - Oct 2015

    Fingerprint

    Sympathetic Nervous System
    Cardiovascular Diseases
    Hypertension
    Fatal Outcome
    Sudden Cardiac Death
    Disasters
    Psychological Stress
    Adrenergic Agents
    Heart Diseases
    Emotions
    Myocardial Infarction
    Medicine
    Psychology
    Incidence
    Therapeutics

    Cite this

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    Role of the Sympathetic Nervous System in Stress-Mediated Cardiovascular Disease. / Hering, Dagmara; Lachowska, K.; Schlaich, Markus.

    In: Current Hypertension Reports, Vol. 17, No. 10, 80, 10.2015, p. 1-9.

    Research output: Contribution to journalReview article

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    AU - Lachowska, K.

    AU - Schlaich, Markus

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    N2 - © 2015, Springer Science+Business Media New York. A high incidence of acute cardiovascular events and sudden cardiac death following unexpected acute emotional stress or a natural catastrophic disaster has been well-documented over the past decades. Chronic psychosocial factors have been shown to be directly linked to the development of hypertension, cardiovascular disease and stroke. Activation of various neurogenic pathways is an important mediator of acute and chronic stress-induced hypertension and heart disease. Heightened sympathetic activation has been shown to be a critical contributor linking psychogenic effects on cardiovascular regulation to serious and often fatal CV outcomes. Accordingly, several therapeutic approaches that attenuate autonomic imbalance via modulation of increased sympathetic outflow by either non-pharmacological or interventional means have been shown to alleviate clinical symptoms. Likewise stress reduction per se achieved with transcendental medicine has been linked to improved patient outcomes. Therapies that oppose adrenergic activity and/or have the potential to attenuate negative emotions are likely to reduce cardiovascular risk and its adverse consequences attributable to chronic mental stress.

    AB - © 2015, Springer Science+Business Media New York. A high incidence of acute cardiovascular events and sudden cardiac death following unexpected acute emotional stress or a natural catastrophic disaster has been well-documented over the past decades. Chronic psychosocial factors have been shown to be directly linked to the development of hypertension, cardiovascular disease and stroke. Activation of various neurogenic pathways is an important mediator of acute and chronic stress-induced hypertension and heart disease. Heightened sympathetic activation has been shown to be a critical contributor linking psychogenic effects on cardiovascular regulation to serious and often fatal CV outcomes. Accordingly, several therapeutic approaches that attenuate autonomic imbalance via modulation of increased sympathetic outflow by either non-pharmacological or interventional means have been shown to alleviate clinical symptoms. Likewise stress reduction per se achieved with transcendental medicine has been linked to improved patient outcomes. Therapies that oppose adrenergic activity and/or have the potential to attenuate negative emotions are likely to reduce cardiovascular risk and its adverse consequences attributable to chronic mental stress.

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