Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

Vidya Nambiar

    Research output: ThesisDoctoral Thesis

    Abstract

    This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.
    LanguageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date17 Mar 2017
    StateUnpublished - 2017

    Fingerprint

    Sarcopenia
    Sciatic Nerve
    Peripheral Nerves
    Nervous System
    Spinal Cord
    Peripheral Nervous System
    Inbred C57BL Mouse
    Research
    Axons
    Lower Extremity
    Skeletal Muscle
    Central Nervous System
    Muscles

    Cite this

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    title = "Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves",
    abstract = "This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.",
    keywords = "Sarcopenia, Penpheral nerves, Motor neurons, Autophagy, Aggregates",
    author = "Vidya Nambiar",
    year = "2017",
    language = "English",
    school = "The University of Western Australia",

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    TY - THES

    T1 - Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

    AU - Nambiar,Vidya

    PY - 2017

    Y1 - 2017

    N2 - This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.

    AB - This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.

    KW - Sarcopenia

    KW - Penpheral nerves

    KW - Motor neurons

    KW - Autophagy

    KW - Aggregates

    M3 - Doctoral Thesis

    ER -