Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

Vidya Nambiar

    Research output: ThesisDoctoral Thesis

    538 Downloads (Pure)

    Abstract

    This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date17 Mar 2017
    Publication statusUnpublished - 2017

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