Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

Vidya Nambiar

Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves

Vidya Nambiar

Research output: Thesis › Doctoral Thesis

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Abstract

This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Shavlakadze, Tea, Supervisor Grounds, Miranda, Supervisor Hodgetts, Stuart, Supervisor Harvey, Alan, Supervisor
Award date	17 Mar 2017
Publication status	Unpublished - 2017

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THESIS - DOCTOR OF PHILOSOPHY - NAMBIAR Vidya - 2017
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title = "Role of the nervous system in sarcopenia: age related molecular and morphological changes in murine peripheral nerves and spinal cords, and analysis of the effects of resistance exercise on old sciatic nerves",

abstract = "This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.",

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N2 - This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.

AB - This PhD research studied the role of the peripheral and central nervous system, in the context of the age related loss of skeletal muscle mass and function(sarcopenia). A time course study using ageing C57BL/6J mice, revealed striking age-related morphological, molecular and cellular changes in the peripheral nerve axons innervating the lower limb muscles and lumbar spinal cords, associated with the progression of sarcopenia. Another major experiment showed that while the mid-life onset on increasing resistance wheel exercise prevented sarcopenia, this exercise had little effect on the old peripheral nerves. This research provides new insight into the ageing neuromuscular system.

KW - Sarcopenia

KW - Penpheral nerves

KW - Motor neurons

KW - Autophagy

KW - Aggregates

M3 - Doctoral Thesis

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